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논문 기본 정보

자료유형
학술저널
저자정보
Althneibat Thabet Hasan Ahmad (Department of Clinical Pharmacy, Faculty of Pharmacy, Mutah University, Al-Karak, Jordan) Maaty Doaa Ahmed Mohamed (Department of Botany and Microbiology, Faculty of Science, Al-Azhar University, Girls Branch, Cairo, Egypt) Gaber Yasser (Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Mutah University, Al-Karak, Jordan) Youssef Ahmed Mohamed Mohamed (Department of Pharmacology, Faculty of Pharmacy, Mutah University, Al-Karak, Jordan)
저널정보
대한약침학회 Journal of Pharmacopuncture Journal of Pharmacopuncture Vol.27 No.3
발행연도
2024.9
수록면
223 - 233 (11page)
DOI
10.3831/KPI.2024.27.3.223

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Objectives: The phytochemicals in the aerial parts of Euphorbia paralias (also known as Sea Spurge) and their anti-inflammatory and antimicrobial activities were investigated. Methods: The methanolic extract was characterized using GC-MS and HPLC techniques. The anti-inflammatory feature was estimated through a Human Red Blood Cell (HRBC) membrane stabilization technique, while the antimicrobial feature was evaluated by the disc diffusion agar technique, minimum bactericidal concentration, and minimum inhibitory concentration (MIC) via micro-broth dilution method. Results: The GC/MS results demonstrated the existence of various phytochemicals, such as n-hexadecenoic acid, cis-11-eicosenoic acid, and methyl stearate, recognized for their anti-inflammatory and antibacterial features. The similarity of the phytochemical composition with other Euphorbia species emphasizes the genus-wide similarity. The antiinflammatory activity exhibited a noteworthy inhibitory effect comparable to the reference drug indomethacin. The extract’s antimicrobial potential was tested against a range of microorganisms, demonstrating significant action against Gram-positive bacteria and Candida albicans . The quantification of total phenolics and flavonoids further supported the therapeutic potential of the extract. Conclusion: The methanolic extract from E. paralias emerges as a successful natural source of important active constituents with potential applications as anti-inflammatory and antimicrobial agents. This research provides a first step to valorize Euphorbia paralias insights as a source of worthwhile phytochemicals that have potential applications in the pharmaceutical industry.

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