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논문 기본 정보

자료유형
학술저널
저자정보
Xingchen Li (Peking University People's Hospital) Yiqin Wang (Peking University People's Hospital) Jiaqi Wang (Department of Obstetrics and Gynecology, Peking University People’s Hospital, Beijing, China) Jingyi Zhou (Peking University People's Hospital) Jianliu Wang (Peking University People's Hospital)
저널정보
대한부인종양학회 Journal of Gynecologic Oncology Journal of Gynecologic Oncology Vol.35 No.4
발행연도
2024.7
수록면
1 - 13 (13page)
DOI
https://doi.org/10.3802/jgo.2024.35.e42

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초록· 키워드

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Objective: This study aims to assess the impact of the metabolic risk score (MRS) on timeto achieve complete remission (CR) of fertility-sparing treatments for atypical endometrialhyperplasia (AEH) and early endometrial cancer (EC) patients. Methods: Univariate and multivariate cox analyses were employed to identif y independentrisk factors affecting the time to CR with patients at our center. These factors weresubsequently incorporated into receiver operator characteristic cur ve analysis and decisioncur ve analysis to assess the predictive accuracy of time to CR. Additionally, Kaplan–Meieranalysis was utilized to determine the cumulative CR rate for patients. Results: The 173 patients who achieved CR following fertility preser vation treatment (FPT)were categorized into three subgroups based on their time to CR (<6, 6–9, >9 months). Bodymass index (hazard ratio [HR]=0.20; 95% confidence inter val [CI]=0.03, 0.38; p=0.026),MRS (HR=0.31; 95% CI=0.09, 0.52; p=0.005), insulin resistance (HR=1.83; 95% CI=0.05,3.60; p=0.045), menstruation regularity (HR=3.77; 95% CI=1.91, 5.64; p=0.001), polycysticovar y syndrome (HR=−2.16; 95% CI=−4.03, −0.28; p=0.025), and histological type (HR=0.36;95% CI=0.10, 0.62; p=0.005) were identified as risk factors for time to CR, with MRSbeing the independent risk factor (HR=0.29; 95% CI=0.02, 0.56; p=0.021). The inclusionof MRS significantly enhanced the predictive accuracy of time to CR (area under the cur ve[AUC]=0.789 for Model 1, AUC=0.862 for Model 2, p=0.032). Kaplan–Meier sur vival cur vesrevealed significant differences in the cumulative CR rate among different risk groups. Conclusion: MRS emerges as a novel evaluation system that substantially enhances thepredictive accuracy for the time to achieve CR in AEH and early EC patients seeking fertilitypreser vation.

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