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논문 기본 정보

자료유형
학술저널
저자정보
정채림 (강원대학교) 최원석 (고려대학교) 윤영경 (고려대학교) 성연희 (고려대학교) 조자현 (서울대학교) 유수현 (강원대학교)
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한국보건의료기술평가학회 보건의료기술평가 보건의료기술평가 제12권 제1호
발행연도
2024.6
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1 - 8 (8page)

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초록· 키워드

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Objectives: This study aims to investigate effectiveness of herpes zoster vaccines. Methods: Systematic searches on OVID-Medline and KoreaMed were performed on March 6th 2023. Randomized controlled trials (RCTs) and retrospective studies (RSs) were included, and a qualitative analysis was conducted. The outcomes of interest included protection against herpes zoster and related complications. Results: A total of six RCTs and twelve RSs were included in the analysis: one RCT and eight RSs of zoster vaccine live (ZVL), and five RCT and four RSs of recombinant zoster vaccine (RZV). Protection against herpes zoster by ZVL was approximately 50% in one year after vaccination, and the effectiveness decreased to 14%–39% after five years. Protection of herpes zoster by RZV was maximum 89% in two years, and the effectiveness decreased to 84% after 7–8 years and 73% after ten years. Conclusion: Compared to ZVL, RZV was judged to be more effective in protection against herpes zoster and showed a smaller decrease over time. We expect that this information can serve as a basis for policy making processes regarding the national immunization program in Korea.

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