지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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Surface-enhanced Raman scattering (SERS)-based immunoassays have been developed for fast and ultrasensitive detection of biomarkers. In this study, we report a SERS-based sandwich immunoassay for the detection of the Alzheimer’s disease biomarker amyloidβ(Aβ). A method combining magnetic separation and SERS was developed to detection of Aβ. Gold-coated magnetic nanoparticles (Fe3O4@Au MNPs) were prepared by immobilizing anti-Aβ antibodies and was used in the separation and the concentration of the Aβ. Gold nanoparticles (Au NPs) were modified with detection antibodies, and antibody-conjugated Au NPs were labeled with 3, 3, diethylthiatricarbocyanine iodide (DTTC), as the SERS probes. The correlation between the Aβ concentration and the SERS signal was found to be linear within the range from 1 fM to 1 µM. As a result, we were able to detect Aβ with a much lower limit of 1 fM. This technique allows for straightforward SERS-based bioassays for the quantitative detection of biomarkers and has potential for clinical applications.
목차
I. INTRODUCTION
II. EXPERIMENTAL METHODS
III. RESULTS AND DISCUSSION
IV. CONCLUSIONS
REFERENCES
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