The purpose of this study was to examine the preventive effects of cabbage and cabbage-mixed juice on acute gastritis and various concentrations of Angelica keiskei Koidz(AK) juice on hepatitis in SD-rats. Using these juices, cell viability in gastric cancer cells (AGS human gastric cancer cells), liver cancer cells (HepG2 human liver cancer cells) was measured by MTT assay, expression of inflammatory genes iNOS, COX-2, TNF-α and IL-1β in the AGS and HepG2 cells was determined by RT-PCR. And neutralizing capacity was tested in vitro. Antigastritic effects on gastric lesions were induced by HCl-ethanol(60% ethanol + 150 mM HCl) in SD-rats; experimental animals weighing 150∼200 g were divided into 9 groups: Normal (1 mL of saline without HCl-ethanol treatment), Control (HCl-ethanol treated group), CL (400 mg/kg of cabbage juice-low treated group), CH (800 mg/kg of cabbage juice-high treated group), CKL (280 mg/kg of Cabbage juice and 120mg/kg kale juice-low treated group), CKH (560 mg/kg of Cabbage juice and 240mg/kg kale juice-high treated group), CChL (280 mg/kg of Cabbage juice and 120mg/kg Chlorella extract-low treated group), CChH (560 mg/kg of Cabbage juice and 240mg/kg Chlorella extract-high treated group) and Cimetidine (80 mg/kg of cimetidine treated group, positive control), respectively. At the 2 mg/ml concentration, the AGS cell growth inhibitory rate was 20% in chlorella, 21% in kale, and 42% in cabbage. Replacement of 30% of cabbage with chlorella exhibited growth inhibition rate of 57%, and the replacement with kale exhibited 65% inhibition as well. Neutralizing capacity of cabbage-mixed juices were 40.1% in chlorella, 44.9% in kale, higher than that of cabbage juice(34.8). The inhibition rates (%) on the acute gastritis induced by HCl-ethanol in the rats were shown as follows, 47% in CH, 71% in CChH, 75% in CKH, and 75% in cimetidine compared with the Control, respectively. Supplementarily, groups of CKH and CChH showed decrease in the volume of gastric secretion and acid output, but increased pH. Addition of chlorella or kale to the cabbage juice was found to have synergetic effects on suppression of gastric lesion in the acute gastritis model. Especially, cabbage-mixed kale juice elevated an inhibitory effect to be close to the level of positive control group(Cimetidine). Acute hepatitis models induced with acetaminophen using Sparague-Dawley male(5w) rats weighing 180~200g were employed to determine the preventive effect of AK divided into 7 groups of normal group(Nor), control group(APAP treated, Con). Various concentrations of AK juice was studied; 60 mg/kg (AK60), 120 mg/kg (AK120), 240 mg/kg (AK240), 480 mg/kg (AK480), 600 mg/kg (AK600), and positive control group (Silymarin 100 mg/ml, Sily). Each group was sacrified after feeding the juice samples for 2 weeks and assessed on blood biochemical biomarkers by enzyme assay methods and acvtivities of catalase and SOD, contents of glutathione and GSH-perocidase in the liver and H&E staining hispathological analyses. APAP treatment (800 mg/ml) caused liver injury as indicated by their significantly elevated plasma AST, ALT levels. Depending on different concentrations, of AK juice, differences in the liver protective activities were observed. Low concentration group(AK60) showed no significant protective effects, however medium concentration groups (AK120, AK240) showed protective effects to be close to the level in inhibitory ratio of positive control group(Silymarin). Adversely, high concentration groups (AK480, AK600) showed lower protective effects than the medium concentration groups. In conclusions, first, cabbage-mixed juices, especially cabbage-kale, exhibited remarkable antigastritic effects and could be administered for a long period in the prevention and treatment of the gastritis. Seconds, appropriate concentration of Angelica keiskei juice could have strong protective effects against acetaminophen-induced hepatotoxicity in rat model.