Purpose : This study was to evaluate the efficacy of Nei-Guan acupressure on nausea and vomiting in patients who had applied the intravenous patient controlled analgesia(IV-PCA). Methods : The data was collected during the period from August 13, 2012 to January 31, 2013 at a hospital in Busan province. To control the variable, the subjects who underwent surgery a laparoscopic prostatectomy with IV-PCA were randomly assigned to a wrist band group, a sticker push rod group, and a control group. There were 45 males in total with each group consisting of 15 subjects. The degree of nausea was measured by NRS, and the vomiting was measured by the number of vomiting and retching. A wrist band group and a sticker push rod group were applied nei-guan acupressure for five hours and rested 1 hour from ward immediately before entering operating room. This process has been provided 4 times for 24 hours. The data was analyzed by descriptive statistics, x²-test, repeated measures ANOVA and Games-Howell test in PASW 18.0. Results : Nei-Guan acupressure had an effect on nausea about interaction between group and time (F=5.012, p<.001), group(F=10.796, p<.001), time(F=26.512, p<.001) in a laparoscopic prostatectomy with IV-PCA. Also, it had an effect on vomiting about interaction between group and time (F=2.768, p=.032), group(F=8.888, p=.001), time(F=4.009, p=.022). Conclusion : The result of this study could potentially confirm that nei-guan acupressure is an effective therapy for the prevention of nausea and vomiting which occurred by applying the IV-PCA. Therefore, when patients complain of nausea and vomiting which was occurred by applying the IV-PCA, nurses should provide information about nei-guan acupressure wrist band and sticker push rod to patients and try to release them for nausea and vomiting.