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이용수22
이 논문의 연구 히스토리 (4)
2013
pH 감응성을 지닌 alginate/poly(vinyl alcohol)/bentonite 블렌드 비드의 제조 및 특성
정경희
,
정영진
생체재료학회지
2013.12
학술저널
Preparation and characterization of pH-sensitive sodium alginate/poly(vinyl alcohol)/bentonite blend beads for controlled release of drug
정경희
,
정영진
한국고분자학회 학술대회 연구논문 초록집
2013.10
학술대회자료
Preparation and characterization of pH-sensitive sodium alginate/poly(vinyl alcohol)/bentonite blend beads for controlled release of diclofenac sodium
정경희
,
강세미
,
이재호
외 2명
한국고분자학회 학술대회 연구논문 초록집
2013.04
학술대회자료
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- 연관 학술논문 또는 학술발표를 통해 보다 발전된 연구결과를 확인하실 수 있습니다.
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초록· 키워드
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Sodium alginate can form a reticulated structure when it contacts with Ca2+ and thus it have been many efforts to use alginate beads as oral drug delivery carriers due to their pH responsive swelling behavior. However, alginate beads have some serious problems.
In order to enhance the drug entrapment efficiency and improve the swelling behaviors of drug delivery system, it was prepared the beads by adding poly(vinyl alcohol)(PVA) and bentonite. Sodium alginate/PVA/bentonite beads of different compositions were prepared by varying the amount of bentonite.
The beads were characterized by fourier transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM). The swelling and pH-sensitive properties of the beads were examined in pH 1.2 and 7.4 at 37℃. Drug loading and controlled release properties of the beads were also evaluated using diclofenac sodium as the model drug.
The beads are spherical and have smooth surface. The encapsulation efficiency of the prepared beads increased with increasing the amount of PVA and bentonite. The swelling of the beads was influenced by pH of solution, PVA, and bentonite content. The swelling measurements of the beads supported the release results. With the addition of PVA, these beads show decreased swelling capacity but increased stability in PBS of pH 7.4. Drug release at pH 7.4 was more rapid than that at pH 1.2, due to swelling and erosion of beads at pH 7.4.
The results also indicated that the quantity of the bentonite and PVA added to the sodium alginate beads are the key factor in obtaining such suitable properties required for drug release system.
In order to enhance the drug entrapment efficiency and improve the swelling behaviors of drug delivery system, it was prepared the beads by adding poly(vinyl alcohol)(PVA) and bentonite. Sodium alginate/PVA/bentonite beads of different compositions were prepared by varying the amount of bentonite.
The beads were characterized by fourier transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM). The swelling and pH-sensitive properties of the beads were examined in pH 1.2 and 7.4 at 37℃. Drug loading and controlled release properties of the beads were also evaluated using diclofenac sodium as the model drug.
The beads are spherical and have smooth surface. The encapsulation efficiency of the prepared beads increased with increasing the amount of PVA and bentonite. The swelling of the beads was influenced by pH of solution, PVA, and bentonite content. The swelling measurements of the beads supported the release results. With the addition of PVA, these beads show decreased swelling capacity but increased stability in PBS of pH 7.4. Drug release at pH 7.4 was more rapid than that at pH 1.2, due to swelling and erosion of beads at pH 7.4.
The results also indicated that the quantity of the bentonite and PVA added to the sodium alginate beads are the key factor in obtaining such suitable properties required for drug release system.
목차
1.서론 11.1. 약물전달 시스템 11.1.1. 제어방출시스템(Cotrolled release system) 11.1.2. 표적지향시스템(Targeted or Site-specific System) 21.1.3. 자극감응시스템(Stimuli-responsive System) 21.2. 점토(Clay) 31.3. Alginate 71.4. Poly(vinyl alcohol) 111.5. Diclofenac sodium 141.6. 연구 목적 172.실험 192.1. 재료 192.2. 제조 192.3. 분석 222.3.1. Scanning Electron Microscope(SEM) 관찰 222.3.2. Fourier transform infrared spectroscopy(FT-IR) 222.3.3. 팽윤 특성 측정 222.3.4. 약물 봉입 효율 232.3.5. 약물 방출 거동 233.결과 및 고찰 253.1. Bead 제조 및 특성 분석 253.2. Bead의 Morphology 273.3. FT-IR spectra 293.4. pH에 따른 팽윤도의 특성 313.5. In vitro 약물 방출 374.결론 425.참고문헌 44Abstract 51
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