지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학위논문
- 저자정보
- 지도교수
- 정노희
- 발행연도
- 2014
- 저작권
- 충북대학교 논문은 저작권에 의해 보호받습니다.
이용수2
이 논문의 연구 히스토리 (2)
- 이 논문의 후속연구가 궁금하신가요?
- 연관 학술논문 또는 학술발표를 통해 보다 발전된 연구결과를 확인하실 수 있습니다.
- 이 논문의 연구 히스토리 확인하기
초록· 키워드
오류제보하기
In this study, The Arctigenin was obtained by using supercritical fluid extraction and bioconversion process from Arctii Fructus. Arctigenin is efficacious anti-inflammatory and anti-influenza. For this reason, Arctigenin is studied in various field.
It was identified as 4-[(3,4-Dimethoxyphenyl)methyl)]dihydro-3-[(4-hydroxy
-3-methoxyphenyl)methyl]-2(3H)-furanone (arctigenin) by FT-IR, 1H-NMR and the purity of it was 95.1% by HPLC analysis. The optimum conditions for supercritical extraction were confirmed that the temperature is 40℃ and the pressure is 300 bar. Arctigenin inhibited tyrosinase (up to 85.06±0.9 % at 260 ㎍/㎖ concentration) and melanin synthesis in a dose dependent manner (up to 51.1±3.7 % at the concentration of 3.0 ㎍ / ㎖). The results were better than arbutin. In observation of the content of active substance that is dissolved 1,3-butylene glycol, in change of temperature and pH for 4 weeks, the potency is more than 95%. Therefore, It is expected that manufactured Arctigenin is useful for whitening cosmetics.
It was identified as 4-[(3,4-Dimethoxyphenyl)methyl)]dihydro-3-[(4-hydroxy
-3-methoxyphenyl)methyl]-2(3H)-furanone (arctigenin) by FT-IR, 1H-NMR and the purity of it was 95.1% by HPLC analysis. The optimum conditions for supercritical extraction were confirmed that the temperature is 40℃ and the pressure is 300 bar. Arctigenin inhibited tyrosinase (up to 85.06±0.9 % at 260 ㎍/㎖ concentration) and melanin synthesis in a dose dependent manner (up to 51.1±3.7 % at the concentration of 3.0 ㎍ / ㎖). The results were better than arbutin. In observation of the content of active substance that is dissolved 1,3-butylene glycol, in change of temperature and pH for 4 weeks, the potency is more than 95%. Therefore, It is expected that manufactured Arctigenin is useful for whitening cosmetics.
목차
Ⅰ. 서 론 1Ⅱ. 실 험 4Ⅱ-1. 재료 및 장치 4Ⅱ-2. 실험 방법 5Ⅱ-2-1. 우방자로부터 악티게닌의 제조 5Ⅱ-2-2. 티로시나아제 저해효과 측정 5Ⅱ-2-3. 세포독성 및 멜라닌 생성억제효과 측정 7Ⅱ-2-4. 악티게닌 안정성 측정 8Ⅱ-3. 기기 분석 8Ⅱ-4. 악티게닌 함유 스킨과 크림 제조 및 안정성 9Ⅲ. 결과 및 고찰 15Ⅲ-1. 우방자 추출물의 제조 및 안정성 15Ⅲ-2. 분석결과 20Ⅲ-3. In vitro 미백효과 측정 20Ⅲ-3-1. 티로시나아제 저해효과 측정 20Ⅲ-3-2. 멜라닌 생성억제효과 측정 24Ⅲ-4. 악티게닌 함유 스킨과 크림의 평가 25Ⅳ. 결 론 32참고문헌 34
최근 본 자료
댓글(0)
0