Restricted supply of nutrients are one of the big stress to body, which may affects gene expression on the molecular level and physiological functions. Understanding of cellular responses during starvation is necessary in developing strategies to reduce damages caused by starvation-stress or diet. Glutamic-oxaloacetic transaminase 1 (Got1) is a pyridoxal phosphate-dependent enzyme which exists in cytoplasmic membrane, plays a role in amino acid metabolism and the urea and tricarboxylic acid cycles; Biosynthesis of L-glutamate from L-aspartate or L-cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Got1 associated diseases are including ochoa syndrome, and gallbladder disease. Methionine adenosyltransferase 1 (Mat1) is a protein-coding gene. The gene catalyzes a two-step reaction that involves the transfer of the adenosyl moiety of ATP to methionine to form S-adenosylmethionine and tripolyphosphate, which is subsequently cleaved to PPi and Pi. S-adenosylmethionine is the source of methyl groups for most biological methylations. The most well known disease is methionine adenosyltransferase deficiency. From 1 h of starvation, Got1 gene expression is increased and then 24 hours after its gene expression is returned to the normal state. Mat1 gene expression is continuously increased by starvation from 1 h to until 24 h. Starvation stress on the expression of the ER stress chaperone PDI, ERp29 expression only difference between males and females showed the opposite. Rat by starvation for 1-3 days is a significant change in expression of genes Got1 although invisible, Mat1 gene expression is significantly reduced in the cerebral cortex and cerebellum whereas the 1-2 days of lung gene expression is increased by starvation while decreased expression of the third day. Starvation by the heart so as not to observe gene expression is reduced. Got1 lung gene expression in the food supply only one day after the starvation group showed very strong expression. Muscle is significantly reduced expression of starvation after the start and at the same time two days after starvation for one day food supply has returned to normal state. Mat1a meaningful gene expression did not change. Got1 ♂ Gene expression is supplied, the NaCl by showing strong expression in the lung, the thymus, the apparent decreased expression of the remaining changes are not observed. If the water supply is more than ♀ supplied by both NaCl showed weaker expression patterns. In the case of gene expression Mat1a ♂ NaCl supplied by the lung, kidney, muscle expression was observed rising from about however. In the case of supply by ♀ NaCl elevated expression is not observed.