Stair descent is a strenuous daily activity that requires a large range of motion in the lower extremity joints. Fall on stairs often results in severe injury and occurs twice in female population. The gender differences of intrinsic factor can give different stair-descent strategies between genders. However, gender differences in kinetics and kinematics of the lower extremity are unknown. Thus, the purpose of this study was to determine whether the gender differences of knee and ankle kinematics and kinetics exist in sagittal plane during stair descent. Fifteen male and fifteen female subjects were recruited and performed stair descent. Kinetic and kinematic data were obtained using force plate and motion capture system. Women performed stair descent with greater peak ankle dorsiflexion angle (p<0.05). Women showed higher ankle plantar flexion moment (p<0.05), lower peak knee extension moment (p<0.05), higher peak power at ankle (p<0.05), lower peak power at knee(p<0.05), and higher ankle joint negative work (p<0.05) at early weight acceptance phase. In addition, Women revealed higher ground-toe-trochanter (GTT) angle (p<0.05) and lesser ground-toe (GT) length (p<0.05), which indicated more forward position of lower extremity relative to toe contact point, at initial contact and at the time of peak kinematics and kinetic events. This study found that knee and ankle kinematics and kinetics were significantly different between genders due to gender differences of GTT angle. Women have different stair-descent strategy compare to men that reducing the demand of lower extremity muscle function but this strategy seems to increase the risk of fall on stairs. The height was correlated to GTT angle and peak kinematic and kinetic events. Thus, height could be one of factors affects to kinematics and kinetics differences between gender.