지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학위논문
- 저자정보
- 지도교수
- 임윤경
- 발행연도
- 2015
- 저작권
- 대전대학교 논문은 저작권에 의해 보호받습니다.
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초록· 키워드
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Objective : The purpose of this study was to evaluate the effects of Polyporus herbal-acupuncture (PO-HA) at KI10 (Umgok) on nephritis induced by lipopolysaccharide(LPS) in rats.
Methods : Rats were allocated into normal, control, and 2 experimental groups. The rats in the control group were intra-peritoneally injected with LPS for nephritis induction. The rats in the groups of experiment 1 and experiment 2 were treated with saline injection, and PO-HA, respectively at KI10 three times for a week and then intra-peritoneally injected with LPS. To evaluate the effects of PO-HA at KI10, WBC count in blood, creatine, TNF-α, CINC-1 in serum, urinary volume, creatinine, total protein in urine, MPO in kidney were measured.
Results : PO-HA at KI10 significantly suppressed the increase of WBC in blood, TNF-α, CINC-1 in serum, MPO in kidney of LPS-stimulated rats. PO-HA at KI10 significantly suppressed the increase creatinine, total protein in urine of LPS-stimulated rats.
Conclusion : According to these results, it is postulated that PO-HA at KI10 has an anti-inflammatory and renal-protective effects on LPS-induced nephritis in rats. Therefore, it is suggested that PO-HA at KI10 may be an useful therapeutics for nephritis in clinical field after further researches.
Methods : Rats were allocated into normal, control, and 2 experimental groups. The rats in the control group were intra-peritoneally injected with LPS for nephritis induction. The rats in the groups of experiment 1 and experiment 2 were treated with saline injection, and PO-HA, respectively at KI10 three times for a week and then intra-peritoneally injected with LPS. To evaluate the effects of PO-HA at KI10, WBC count in blood, creatine, TNF-α, CINC-1 in serum, urinary volume, creatinine, total protein in urine, MPO in kidney were measured.
Results : PO-HA at KI10 significantly suppressed the increase of WBC in blood, TNF-α, CINC-1 in serum, MPO in kidney of LPS-stimulated rats. PO-HA at KI10 significantly suppressed the increase creatinine, total protein in urine of LPS-stimulated rats.
Conclusion : According to these results, it is postulated that PO-HA at KI10 has an anti-inflammatory and renal-protective effects on LPS-induced nephritis in rats. Therefore, it is suggested that PO-HA at KI10 may be an useful therapeutics for nephritis in clinical field after further researches.
목차
Ⅰ. 서 론 1Ⅱ. 실 험 31. 재료 31) 동물 32) 약재 33) 시약 및 기기 4⑴ 시약 4⑵ 기기 42. 방법 51) 약침액의 제조 52) 세포독성 7(1) 간세포 분리 7(2) MTT assay 73) 신장염 동물 모델 74) 실험군 분류 및 처치 85) 결과 분석 8(1) 혈액 분석 8(2) 소변 분석 9(3) 신장 내 염증활성 평가 9(4) 통계분석 9Ⅲ. 성 적 101. 저령 약침액의 세포독성 102. 음곡 저령 약침이 rat의 신장염에 미치는 영향 111) 혈액 분석 11(1) WBC in blood 12(2) serum Creatinine 13(3) serum TNF-α 14(4) serum CINC-1 152) 소변 분석 16(1) 이뇨 활성 17(2) Creatinine in urine 18(3) Total protein in urine 193) Renal MPO 분석 20Ⅳ. 고 찰 22Ⅴ. 결 론 26참고문헌 27Abstract 31
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