지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학위논문
- 저자정보
- 발행연도
- 2015
- 저작권
- 대전대학교 논문은 저작권에 의해 보호받습니다.
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ABSTRACTS
Objective : The purpose of this study is to investigate the effects of Pyrrosiae Herba herbal-acupuncture (PH-HA) at KI10 (Umgok) on nephritis induced by lipopolysaccharide (LPS) in rat.
Methods : Rats were assigned to four groups; normal, LPS, saline and PH-HA. Rats in the saline and PH-HA groups, were treated with saline injectionand PH-HA respectively at KI10, three times for a week. All animals except those in the normal group were injected intra-peritoneally with LPS to induce nephritis. WBC, in blood, TNF-α, CINC-1, BUN, creatinine in serum, urinal volume, total protein and creatinine in urine, and renal MPO were analyzed.
Results :
1. PH-HA group showed significantly reduced levels of serum BUN, serum creatinine, TNF-α, and CINC-1 compared to LPS group. Furthermore, a significant increase in urine output and significant decreases in total protein in urine, MPO in renal tissue were observed in PH-HA group compared to LPS group
2. PH-HA group showed significantly reduced levels of serum creatinine and renal MPO. and a significant increase in urine output compared to saline group.
Conclusion : According to these results, it is postulated that PH-HA at KI10 has anti-inflammatory and renal-protective effects on LPS-induced nephritis in rat, and both acupoint KI10 and herb Pyrrosiae Herba made contributions to these effects. Further studies on the interaction between acupoint KI10 and herb Pyrrosiae Herba may be needed.
Key words : Pyrrosiae Herba, herbal-acupuncture, KI10, LPS, nephritis
Objective : The purpose of this study is to investigate the effects of Pyrrosiae Herba herbal-acupuncture (PH-HA) at KI10 (Umgok) on nephritis induced by lipopolysaccharide (LPS) in rat.
Methods : Rats were assigned to four groups; normal, LPS, saline and PH-HA. Rats in the saline and PH-HA groups, were treated with saline injectionand PH-HA respectively at KI10, three times for a week. All animals except those in the normal group were injected intra-peritoneally with LPS to induce nephritis. WBC, in blood, TNF-α, CINC-1, BUN, creatinine in serum, urinal volume, total protein and creatinine in urine, and renal MPO were analyzed.
Results :
1. PH-HA group showed significantly reduced levels of serum BUN, serum creatinine, TNF-α, and CINC-1 compared to LPS group. Furthermore, a significant increase in urine output and significant decreases in total protein in urine, MPO in renal tissue were observed in PH-HA group compared to LPS group
2. PH-HA group showed significantly reduced levels of serum creatinine and renal MPO. and a significant increase in urine output compared to saline group.
Conclusion : According to these results, it is postulated that PH-HA at KI10 has anti-inflammatory and renal-protective effects on LPS-induced nephritis in rat, and both acupoint KI10 and herb Pyrrosiae Herba made contributions to these effects. Further studies on the interaction between acupoint KI10 and herb Pyrrosiae Herba may be needed.
Key words : Pyrrosiae Herba, herbal-acupuncture, KI10, LPS, nephritis
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