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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학위논문
- 저자정보
- 지도교수
- 魏通順
- 발행연도
- 2016
- 저작권
- 동신대학교 논문은 저작권에 의해 보호받습니다.
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Objectives : This research was performed to investigate the effects of Ukgansan pharmacopuncture(U-PA) of focal brain ischemia induced by middle cerebral artery occlusion(MCAO) in rats.
Methods : The subjects were divided into 5 groups : Control group, Acupuncture group, Pharmacopuncture group U-PA1(2.571 mg/ 250 g/ 40 ㎕), Pharmacopuncture group U-PA2(6.428 mg/ 250 g/ 40 ㎕), Pharmacopuncture group U-PA3(12.855 mg/ 250 g/ 40 ㎕). The focal brain ischemia was induced by intraluminal filament insertion into middle cerebral artery. After 3 days of MCAO, Ukgansan(UGS) pharmacopuncture was treated into GB20, and the day after treating pharmacopuncture Morris water maze test were carried out by assigned group. The series of process were treated for 6 times. Thereafter Bax, Bcl-2, Bax/Bcl-2 ratio, mGluR5, density of neuronal cell, ChAT were measured.
Results : The results were as follows.
1. The intensity of Bax significantly decreased in U-PA1, U-PA2, U-PA3 group.
2. The Bax/Bcl-2 ratio significantly decreased in U-PA3 group compared with control group.
3. The neuroprotective effect in the hippocampal CA1 significantly increased in U-PA1, U-PA2, U-PA3 groups compared with control group.
4. The density of ChAT in the hippocampal CA1 significantly increased in U-PA1, U-PA2, U-PA3 groups compared with control group.
Conclusions : These results suggest that UGS pharmacopuncture may have anti-apoptotic and neuroprotective effects on focal cerebral ischemia caused by intraluminal filament insertion into middle cerebral artery in rats.
Methods : The subjects were divided into 5 groups : Control group, Acupuncture group, Pharmacopuncture group U-PA1(2.571 mg/ 250 g/ 40 ㎕), Pharmacopuncture group U-PA2(6.428 mg/ 250 g/ 40 ㎕), Pharmacopuncture group U-PA3(12.855 mg/ 250 g/ 40 ㎕). The focal brain ischemia was induced by intraluminal filament insertion into middle cerebral artery. After 3 days of MCAO, Ukgansan(UGS) pharmacopuncture was treated into GB20, and the day after treating pharmacopuncture Morris water maze test were carried out by assigned group. The series of process were treated for 6 times. Thereafter Bax, Bcl-2, Bax/Bcl-2 ratio, mGluR5, density of neuronal cell, ChAT were measured.
Results : The results were as follows.
1. The intensity of Bax significantly decreased in U-PA1, U-PA2, U-PA3 group.
2. The Bax/Bcl-2 ratio significantly decreased in U-PA3 group compared with control group.
3. The neuroprotective effect in the hippocampal CA1 significantly increased in U-PA1, U-PA2, U-PA3 groups compared with control group.
4. The density of ChAT in the hippocampal CA1 significantly increased in U-PA1, U-PA2, U-PA3 groups compared with control group.
Conclusions : These results suggest that UGS pharmacopuncture may have anti-apoptotic and neuroprotective effects on focal cerebral ischemia caused by intraluminal filament insertion into middle cerebral artery in rats.
목차
ABSTRACT iⅠ. 서 론 1Ⅱ. 재료 및 방법 31 실험 재료 3(1) 동물 3(2) 약침액 조제 32. 실험 방법 4(1) Middle Cerebral Artery Occlusion(MCAO)에 의한 허혈성 국소 뇌손상 유발 4(2) 군 분리 및 시술 5(3) 취혈 및 시술 5(4) Morris water maze test 5(5) Reverse Transcription Polymerase Chain Reaction (RT-PCR) 6(6) Immunohistochemistry 83. 통계처리 9Ⅲ. 결 과 111. 단기 기억에 미치는 영향 112. 장기 기억에 미치는 영향 133. Bax 발현에 미치는 영향 144. Bcl-2 발현에 미치는 영향 155. Bax/Bcl-2 ratio에 미치는 영향 166. mGluR5 발현에 미치는 영향 177. 신경세포 손상 방어효과에 미치는 영향 188. Choline acetyltransferase(ChAT) 발현에 미치는 영향 20Ⅳ. 고 찰 22Ⅴ. 결 론 29참고문헌 31
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