목차

CONTENTS 1
LIST OF SCHEME 5
LIST OF TABLE 6
LIST OF FIGURE 7
1 PHOSPHOLIPID-BLOCK-POLY(AMINO ACID)S SYNTHESIZED BY RING OPENING POLYMERIZATION AND ITS SELF-ASSEMBLING BEHAVIORSYSTEM 10
1.1 INTRODUCTION 10
1.2 EXPERIMENT DETAILS 12
1.2.1 Materials 12
1.2.2 Extraction PE from soybean lecithin 12
1.2.3 Synthesis of N-Carboxyanhydride (NCA) of N(α)-t-Butyloxycarbonyl-N(im)-benzyl-L-histidine 13
1.2.4 Synthesis of N-Carboxyanhydride (NCA) of N6-Carbobenzyloxy-L-lysine 14
1.2.5 Synthesis of N-Carboxyanhydride (NCA) of L-Tyrosine 15
1.2.6 Synthesis of N-Carboxyanhydride (NCA) of L-Glutamic acid 5-benzyl ester 16
1.2.7 Synthesis of N-Carboxyanhydride (NCA) of L-Aspartic acid β-benzyl ester 16
1.2.8 Synthesis of N-Carboxyanhydride (NCA) of O-Benzyl-L-serine 17
1.2.9 Synthesis of N-Carboxyanhydride (NCA) of L-alanine 18
1.2.10 Synthesis of N-Carboxyanhydride (NCA) of L-phenylalanine 18
1.2.11 Synthesis of N-Carboxyanhydride (NCA) of L-leucine 18
1.2.12 Synthesis of N-Carboxyanhydride (NCA) of L-isoleucine 19
1.2.13 Synthesis of PE-block-Poly(Amino Acid)s 19
1.2.14 Deprotection reactions of protecting groups 20
1.2.15 Fabrication of the polymeric micelles 20
1.2.16 Characterizations 21
1.3 RESULTS AND DISCUSSION 22
1.3.1 Extraction of PE and characterization 22
1.3.2 Synthesis of NCAs using various amino acids 22
1.3.3 Synthesis of PE-block-Poly(Amino Acid)s 23
1.3.4 Preparation and Characterization of Polymeric Micelles 25
1.4 CONCLUSIONS 26
1.5 REFERENCES 27
2 DUMBBELL-TYPE HYPERBRANCHED POLYGLYCIDOL ASSISTED GREEN SYNTHETIC PROTOCOLS FOR THE PREPARATION OF METAL NANOPARTICLESDELIVERY SYSTEM 44
2.1 INTRODUCTION 44
2.2 EXPERIMENT DETAILS 45
2.2.1 Materials 45
2.2.2 Synthesis of dHBP 46
2.2.3 Preparation of Au NPs 47
2.2.4 Preparation of Ag NPs 47
2.2.5 Preparation of bimetallic NPs 48
2.2.6 Characterizations 48
2.3 RESULTS AND DISCUSSION 49
2.3.1 Synthesis of dHBP 49
2.3.2 Preparation of monometallic NPs 50
2.3.3 Preparation of bimetallic NPs 54
2.4 CONCLUSIONS 57
2.5 REFERENCES 58