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논문 기본 정보
- 자료유형
- 학위논문
- 저자정보
- 지도교수
- 황선철
- 발행연도
- 2017
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이 논문의 연구 히스토리 (2)
2017
A Review of the Literature on Culture-Negative Periprosthetic Joint Infection: epidemiology, diagnosis and treatment
윤홍권
의학과
2017.01
학위논문
A Review of the Literature on CultureNegative Periprosthetic Joint Infection: Epidemiology, Diagnosis and Treatment
윤홍권
,
조성희
,
이동영
외 6명
Knee Surgery and Related Research
2017.01
학술저널
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Purpose: According to the increasing of arthroplasty surgery, the prevalence of periprosthetic joint infection (PJI) also increased. Because identifying microorganism causing PJI is critical to plan treatment strategy, culture-negative (CN) PJI is an important clinical issue. By reviewing previous studies concerning CN PJI, the purpose of the present study is to review epidemiology, diagnosis and treatment for CN PJI in order to help preventing delayed diagnosis and improving clinical outcomes of CN PJI.
Methods: MEDLINE, EMBASE, Cochrane Library and Scopus were screened for articles about CN PJI. Only clinical studies that reported CN PJI and those of written in English were included. In addition, basic science studies for diagnosis, letters to editors, case report and review articles on PJI were excluded in the present study.
Results: Seven studies were included in this study. The prevalence of CN PJI has been reported to range between 0% and 42.1%. The major risk factors for CN PJI are related to prior antibiotics use and presence of postoperative wound drainage. Vancomycin and cephalosporins are most commonly used antibiotics for CN PJI. Two-stage revision followed by 6 weeks of antibiotics therapy has been shown to be the most successful at CN PJI.
Conclusions: In most clinical studies for CN PJI, definite diagnostic method for isolating infected organism or optimal treatment strategy for CN PJI wasn’t explained clearly. Therefore, further study has to be encouraged in order to establish standard diagnostic methods for identifying infecting organism and set up the strategy of treatment for CN PJI.
Methods: MEDLINE, EMBASE, Cochrane Library and Scopus were screened for articles about CN PJI. Only clinical studies that reported CN PJI and those of written in English were included. In addition, basic science studies for diagnosis, letters to editors, case report and review articles on PJI were excluded in the present study.
Results: Seven studies were included in this study. The prevalence of CN PJI has been reported to range between 0% and 42.1%. The major risk factors for CN PJI are related to prior antibiotics use and presence of postoperative wound drainage. Vancomycin and cephalosporins are most commonly used antibiotics for CN PJI. Two-stage revision followed by 6 weeks of antibiotics therapy has been shown to be the most successful at CN PJI.
Conclusions: In most clinical studies for CN PJI, definite diagnostic method for isolating infected organism or optimal treatment strategy for CN PJI wasn’t explained clearly. Therefore, further study has to be encouraged in order to establish standard diagnostic methods for identifying infecting organism and set up the strategy of treatment for CN PJI.
목차
Abstract 1Introduction 3Materials and methods 6Results 9Discussion 12Conclusion 22Appendix 23References 24
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