목차

Abstract 7
1. Introduction 8
1.1 Hydrogel 8
1.1.1 Cryogel 11
1.1.2 Double network hydrogel 13
1.1.3 Hybrid doubl network hydrogel 15
1.2 Application of biocompatible hydrogel 18
1.2.1 Tissue engineering 18
1.2.2 Drug delievery 21
1.3 Poly(aspartic acid), PASP 23
2. Experimental 26
2.1 Materials 26
2.2 Measurements 26
2.2.1 FT-IR spectroscopy 26
2.2.2 Measurements of swelling capacity 27
2.2.3 Morphology 27
2.2.4 Thermal analysis 28
2.2.5 Mechanical property measurement 28
2.2.6 Rheological measurement 28
2.2.7 Synthesis of polysuccinimide (PSI) 29
2.2.8 Synthesis of poly(aspartic acid) (PASP) 30
2.2.9 PSI cryogelation and hydrolysis of macroporous PASP-cryogel 30
2.2.10 Preparation of dually cross-linked PASP-cryogel 32
2.2.11 Preparation of PASP/PAAm semi-IPN hydrogel 32
2.2.12 Preparation of hybrid double network hydrogel 33
3. Results & Discussion 34
3.1 Dually cross-linked PASP cryogel 34
3.1.1 Preparation of dually cross-linked PASP cryogel(M-PASP-cryogel) 34
3.1.2 FT-IR spectroscopy of PASP-cryogel and M-PASP-cryogel 36
3.1.3 Swelling behavior 38
3.1.4 Mechanical test of cryogel and hydrogel 41
3.1.4.1 Compression test of conventional PASP hydrogel and PASP cryogel 43
3.1.4.2 Compression S-S behavior of dually cross-linked PASP cryogel 46
3.1.5 Tensile S-S curves of PASP cryogel 48
3.1.6 Effects of Fe3+ ion concentration on the mechanical properties of M-PASP cryogel 51
3.1.7 Compression S-S curves with different strain limit 53
3.1.8 Morphology 55
3.2 Hybrid double network PASP/PAAm hydrogel 57
3.2.1 FT-IR spectroscopy 58
3.2.2 Swelling behavior 60
3.2.3 Thermal analysis 62
3.2.4 Mechanical properties 64
3.2.4.1 Rheometry 64
3.2.4.2 Tensile behavior of PAAm gel and M-DN gel 67
3.2.5 Mechanical strength of M-DN gel with different content of PAAm 70
3.2.6 Repeated tensile test of Fe-DN gel 72
3.2.7 Morphology 75
4. Conclusion 76
5. References 77
Supplement 85
S1. Compression test for conventional hydrogel and Fe-PASP hydrogel 85
S2. Swelling behavior of PAAm gel and M-PAAm gel 87
S3. Rheometry of PAAM gel and M-PAAm gel 89
S4. Tensile S-S curves of PASP/PAAm semi-IPn gel and M-DN hydrogels 91
Summary in Korean 92