Anti-obesity effect of dairy products with fermented mixed Red Ginseng and Rubus coreanus.



ABSTRACT


Lee, Da-Young
Dept. of Food Biotechnology,
Graduate School of Woosuk University
(Directed by Prof. Oh, Chan-Ho)


This study was investigated the effects of diet containing fermented cheese with fermented mixture of red ginseng and mature fruit of Rubus coreanus extracts. In order to elucidate the inhibition of lipid metabolism, we administered fermented mixture of red ginseng and Rubus coreanus extracts to SD rats with high fat diet. The results are as follows : the body weight was decreased in 5% sample cheese (SC5) group. The periepididymal fat weight of SC5 group and perirenal fat weight of RB100 and SC5 groups compare to control was decreased significantly(respectively 49.0%, 51.5%, 50.8%). In serum, The level of triglyceride was significantly decreased in SC5 group. and glucose was increased in SC5 group. The levels of total cholesterol and HDL-cholesterol were significantly decreased in RB100 group compared to control group. The levels of serum leptin and adiponectin were significantly decreased in RB300 group, and the level of serum insulin was increased in SC10 group compared to control group. The size of adipocyte in corpus of stomach was decreased in SC5 especially. The staining density of lipid deposition within hepatic lobule was weakly stained in all groups. The immunohistochemical density of insulin-secreting cells and GLP-1 secreting cells in the pancreas were significantly higher in SC5 and SC10 groups than the control group. Gastrin and CGRP secreting cell were significantly higher in SC5 and SC10 groups compared to control group. Serotonin secreting cell were significantly lower in RB300 and RB100 groups compared to control group.
These results suggest the cheese with fermented mixture of red ginseng and Rubus coreanus extracts may be used as an anti-obesity biofood.