A tissue engineering scaffold is a three-dimendional substrate which provides a viable environment for organ and tissue regeneration. A variety of biodegradable scaffolds have been introduced over the past decades. However, Mass transfer limitation is still a serious challenge in this field thereby vascularization of scaffold has gained a growing attention. One of the current approaches to address this pervasive issue is to functionalize the scaffold by integrating perfusion channels to prevent the 3D construct from being inaccessible to oxygen and nutrients. In this work, we propose a novel three-dimensional polymer membrane scaffold based on Shellular structure, which comprises two distinct sub-volumes interwinded with each other and separated by a single continuous smooth semi-permeable membrane. One sub-volume is used for cell culture, while the other serves as perfusion channels. This intriguing scaffold integrated with a vascular system, i.e., mass transfer channel, is expected to provide continuous nutrients and oxygen supply to the proliferating cells as well as the removal of waste by the thin semi-permeable membrane. In addition, the Shellular scaffold has biomorphic geometry similar to the triply periodic minimal surface (TPMS) that is ideal to facilitate cellular attachment and realize uniform cell culture. In this work, poly(L-lactic acid) (PLLA) Shellular scaffold has been fabricated based mainly on 3D UV photo-lithography and porogen leaching technique. The water soluble substance, polyethylene glycol (PEG), is chosen here as the pore-forming agent. Surface modification is conducted subsequently to improve the hydrophilicity of scaffold by coating another biomaterial, Polydopamine (PDA) with nano-scale thickness. The mechanical properties, microstructure, wettability and permeability and biocompatibility are evaluated.