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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학위논문
- 저자정보
- 지도교수
- 김재홍
- 발행연도
- 2018
- 저작권
- 동신대학교 논문은 저작권에 의해 보호받습니다.
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Objectives : This study was designed to investigate the effects of Alismatis Rhizoma(AR) pharmacopuncture at BL23 and its mechanism of action on acute renal failure induced by cisplatin.
methods : The rats were devided into Nor group(no injection of cisplatin and no treatment), Con group(no treatment after injection of cisplatin), Acu group(treated of Acupuncture in the position corresponding acupoint of BL23 after injection of cisplatin), AR-PA1 group(treated with 0.3571mg/kg/20μl Concentration of Alismatis Rhizoma pharmacopuncture in the position corresponding acupoint of BL23 after injection of cisplatin), And AR-PA2 group(treated with 1.7855mg/kg/20μl Concentration of Alismatis Rhizoma pharmacopuncture in the position corresponding acupoint of BL23 after injection of cisplatin). Body weight, kidney weight, Tumor Necrosis Factor-alpha(TNF-α), Interleukin-6(IL-6), Cu-Zn Superoxide dismutase(Cu-Zn SOD), Glutathione Peroxidase(GPx), serum BUN, and serum creatinine of each group were measured once a day, for 8 days.
Results : 1. Body weight was significantly increased in some of the AR-PA1 and AR-PA2 groups compared to Con group.
2. Kidney weight was not significantly changed in all experimental groups compared to Con group.
3.TNF-α was significantly decreased in Acu group, AR-PA1 and AR-PA2 group compared to Con group.
4. IL-6 was not significantly changed in all experimental groups compared to Con group.
5. Cu-Zn SOD was significantly increased in the AR-PA2 group compared to Con group.
6.GPx was significantly increased in the AR-PA1 and AR-PA2 groups compared to Con group.
7. Serum BUN and serum creatinine were not significantly changed in all experimental groups compared to Con group.
Conclusions : In the acute renal failure induced by cisplatin, Pharmacopuncture of Alismatis Rhizoma cannot be expected to have effect of restoring glomerular function or suppressing renal edema. However, It is thought to have some protective effects against weight loss, an inhibitory effect on the inflammatory response associated with TNF-α, and protective effect against oxidative stress of kidney tissue.
keywords : Alismatis Rhizoma, Pharmacopuncture, B23, Cisplatin, Acute Renal Failure.
methods : The rats were devided into Nor group(no injection of cisplatin and no treatment), Con group(no treatment after injection of cisplatin), Acu group(treated of Acupuncture in the position corresponding acupoint of BL23 after injection of cisplatin), AR-PA1 group(treated with 0.3571mg/kg/20μl Concentration of Alismatis Rhizoma pharmacopuncture in the position corresponding acupoint of BL23 after injection of cisplatin), And AR-PA2 group(treated with 1.7855mg/kg/20μl Concentration of Alismatis Rhizoma pharmacopuncture in the position corresponding acupoint of BL23 after injection of cisplatin). Body weight, kidney weight, Tumor Necrosis Factor-alpha(TNF-α), Interleukin-6(IL-6), Cu-Zn Superoxide dismutase(Cu-Zn SOD), Glutathione Peroxidase(GPx), serum BUN, and serum creatinine of each group were measured once a day, for 8 days.
Results : 1. Body weight was significantly increased in some of the AR-PA1 and AR-PA2 groups compared to Con group.
2. Kidney weight was not significantly changed in all experimental groups compared to Con group.
3.TNF-α was significantly decreased in Acu group, AR-PA1 and AR-PA2 group compared to Con group.
4. IL-6 was not significantly changed in all experimental groups compared to Con group.
5. Cu-Zn SOD was significantly increased in the AR-PA2 group compared to Con group.
6.GPx was significantly increased in the AR-PA1 and AR-PA2 groups compared to Con group.
7. Serum BUN and serum creatinine were not significantly changed in all experimental groups compared to Con group.
Conclusions : In the acute renal failure induced by cisplatin, Pharmacopuncture of Alismatis Rhizoma cannot be expected to have effect of restoring glomerular function or suppressing renal edema. However, It is thought to have some protective effects against weight loss, an inhibitory effect on the inflammatory response associated with TNF-α, and protective effect against oxidative stress of kidney tissue.
keywords : Alismatis Rhizoma, Pharmacopuncture, B23, Cisplatin, Acute Renal Failure.
목차
ABSTRACTⅠ. 서 론 1Ⅱ. 재료 및 방법 21. 재료 2(1) 동물 2(2) 약침 제조 22. 방법 2(1) Acute Renal Failure(ARF) 유발 2(2) 군 분리 3(3) 취혈 및 처치 3(4) 체중 및 신장무게 측정 3(5) 채혈 및 혈청학적 검사 3(6) Total RNA분리와 Reverse Transcription Polymerase Chain Reaction(RT-PCR) analysis 4① Total RNA 분리 4② Reverse Transcription Polymerase Chain Reaction (RT-PCR) analysis 43. 통계처리 5Ⅲ. 결과 61. 체중변화에 미치는 영향 62. 신장무게 변화에 미치는 영향 83. TNF-α 변화에 미치는 영향 94. IL-6 변화에 미치는 영향 105. Cu-Zn SOD 변화에 미치는 영향 116. GPx 변화에 미치는 영향 127. 혈청 BUN 변화에 미치는 영향 138. 혈청 creatinine 변화에 미치는 영향 14Ⅳ. 고 찰 15Ⅴ. 결 론 20참고문헌 21
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