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논문 기본 정보
- 자료유형
- 학위논문
- 저자정보
- 지도교수
- 하창식
- 발행연도
- 2018
- 저작권
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Among various nanomaterials for drug delivery applications, mesoporous silica nanoparticles (MSNs) are an attractive material as a building block because there are large surface area and pore volumes, favourable biocompatibility, inertness to chemicals, and porous structures that can be tailored to the desired applications.
The basic material, MSNs, was synthesized and functionalized with epoxide group and aminoboronic acid group for surface modification. Then, the drug was supported on the pores of the MSNs, and the pore surface was covered with a reaction with a polyhedral oligomeric silsesquioxane (POSS) as a capping reagent. The connection between the surface of the drug carrier and the capping reagent thus formed is stable under acidic conditions, but is destroyed under neutral conditions. These properties make it possible to withstand the gastrointestinal environment, which is a strong acid when the drug carrier is orally administered, and effectively transfer the drug to the small intestine and the colon. Therefore, the pH-triggered oral drug delivery system is possible to be used for the treatment of colon cancer and other colon diseases.
The basic material, MSNs, was synthesized and functionalized with epoxide group and aminoboronic acid group for surface modification. Then, the drug was supported on the pores of the MSNs, and the pore surface was covered with a reaction with a polyhedral oligomeric silsesquioxane (POSS) as a capping reagent. The connection between the surface of the drug carrier and the capping reagent thus formed is stable under acidic conditions, but is destroyed under neutral conditions. These properties make it possible to withstand the gastrointestinal environment, which is a strong acid when the drug carrier is orally administered, and effectively transfer the drug to the small intestine and the colon. Therefore, the pH-triggered oral drug delivery system is possible to be used for the treatment of colon cancer and other colon diseases.
목차
CHAPTER 1. Introduction 4CHAPTER 2. Literature survey 52-1. Definition and classification of porous materials 52-2. Mesostructure 62-2-1. Liquid crystal templating mechanism 72-2-2. Generalized liquid crystal templating mechanism : Electrostatic interaction 82-2-3. Formation of non-hexagonal mesophase 92-2-4. Hydrogen bonding interaction 102-2-5. True liquid crystal templating mechanism 112-2-6. Formation of other mesophases 112-3. Application of mesoporous silicas 122-3-1. Adsorbents 122-3-2. Separation membranes 132-3-3. Sensors 132-3-4. Catalysts 142-3-5. Drug delivery systems 142-4. Nanovalves 152-4-1. Cargo materials for nanovlave 152-4-2. Activation of nanovalve 162-4-2-1. Light-responsive nanovalve 162-4-2-2. Enzyme-activated nanovalve 172-4-2-3. pH-activated nanovalve 17CHAPTER 3. Synthesis and characterization of functionalized mesoporous silicas for drug delivery 323-1. Experimental 323-1-1. Materials 323-1-2. Synthesis of mesoporous silica 323-1-3. Modification of MSNs using GPTMS and APBA 333-1-4. POSS capping on dye loaded MSNs 333-1-5. POSS capping on drug loaded MSNs 343-1-6. Release test 343-1-7. Confocal laser scanning microscopy (CLSM) 353-1-8. Measurements and characterizations 353-2. Results and discussion 363-2-1. Design pH-triggered oral drug delivery system 363-2-2. Characterization of GPTMS and APBA modified MSNs 373-2-3. Characterization of POSS capped MSNs after dye loading 393-2-4. pH-triggered release of dye 403-2-5. Characterization of POSS capped MSNs after drug loading 423-2-6. pH-triggered release of drug 423-2-7. Cytotoxicity of the drug carrier 433-2-8. Confocal laser scanning microscopy (CLSM) 44CHAPTER 4. Conclusions 70REFERENCES 71ABSTRACT(KOREAN) 77
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