This study was carried out to investigate the growth and inorganic content of the squash (Cucurbita moschata) as affected by hydroponic and fertigation cultivation methods. Coir medium was used for hydroponic and sandy soil which was used for fertigation cultivation in the experiment. All treatments were fed the prescribed nutrient solution based on the recommended concentration for hydroponic cultivation of cucumber nutrient solution. Using irrigation control by integrated solar radiation, hydroponic cultivation was averaged 2-4 L per plant per day, and fertigation cultivation per day was average 0.28-0.57 L per plant. The environmental conditions in the greenhouse were maintained at an average temperature of 25°C, a relative humidity of 85%, CO2 concentration of 400 μmol·mol-1, and the EC and pH of the root zone of the plants were 1.5 dS·m-1 and 6.0, respectively. The seedling was transplanting Dec. 26, 2015 and the final growth measuring was conducted on Feb. 27, 2016. The plant height was 166 cm in hydroponics and 147 cm in fertigation cultivation, and its difference was 19 cm. The difference of leaf length, leaf width, and number of leaf were 1.8 cm, 1.0 cm, 12.6, respectively, it was significantly higher in hydroponic cultivation than fertigation cultivation. The K, Ca and P contents of squash fruits were not significantly different according to the cultivation method but Mg and Fe contents were fertigation cultivation higher than those of hydroponics by 7.1 and 0.1 mg·L-1, respectively showed a significantly difference. The contents of Na, Cu, Zn, and P were 0.7, 0.1, 0.5, and 2.9 mg·L-1 higher in hydroponics than in fertigation cultivation. The number of days until the harvest was 9.0 days for hydroponics and 10.4 days for fertigation cultivation. Consequently, growth and yield of fruits was greater in hydroponic than in fertigation cultivation, and the number of harvesting days was also shortened. This suggests that hydroponic cultivation using coir medium has a positive effect on rhizosphere chemistry and inorganic nutrient uptake of plant than fertigation cultivation on sandy soil.