Objectives: The purpose of this study is to assess antidiabetic effect and safety of Galgunhwangryunhwanggum-tang for type 2 diabetes without complications by analyzing related researches

Methods: For a systematic review and meta-analysis, we searched for antidiabetic effect and safety of Galgunhwangryunhwanggum-tang for type 2 diabetes without complications 10 databases until September 2021. Only randomized controlled trials were chosen.
Results:
1. A total of 17 studies were published after 2012, and all 17 papers were published in China.

2. The average number of study participants was 87.12±25.47, 44.05±12.71 in the intervention group, and 43.05±13.01 in the control group. Most of the studies were for those in their 40s or older, and the duration of the study was 53.76±14.14 days.

3. Most of the articles (16 articles) were on the combination therapy of GGT, and all of them were on the combination with oral hypoglycemic agents.

4. In the treatment effectiveness and meta-analysis, Galgunhwangryunhwanggum -tang had significant improvement effects in fasting plasma glucose level, 2 hour postprandial glucose level, glycated hemoglobin, fasting insulin, and HOMA-IR compared to the control group when treated in parallel with oral glycemic drugs.

5. Eight studies that mediated the parallel treatment of Galgunhwangryunhwanggum-tang and oral hypoglycemic drugs showed adverse reactions, and the main adverse reactions were hypoglycemia, digestive-related adverse(such as nausea, vomiting, diarrhea), and liver dysfunction. Hypoglycemia was the most frequent.

Conclusion: As a result, Galgunhwangryunhwanggum-tang is effective in improving blood sugar and insulin resistance of type 2 diabetes without complications, and can be considered especially in parallel treatment with oral hypoglycemic drugs. A large-scale randomized controlled clinical trial is required that complements the limitations presented in this study in the future.