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- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2003.9
- 수록면
- 120 - 128 (9page)
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Alternative medicines such as herbal products are increasingly being used for preventive and therapeutic purposes. Ginseng is the best known and most popular herbal medicine used worldwide. In spite of some beneficial effects of ginseng on the nervous system, little scientific evidence shows at the cellular level. In the present study, I have examined the direct modulation of ginseng total saponins and individual ginsenosides on the activation of Ca2+ channels and NMDA-gated channels in cultured rat dorsal root ganglion (DRG) and hippocampal neurons, respectively. In DRG neurons, application of ginseng total saponins suppressed high-voltage-activated Ca2+ channel currents and ginsenoside Rg3,
among the 11 ginsenosides tested, produced the strongest inhibition on Ca2+ channel currents. Occlusion experiments using selective Ca2+ channel blockers revealed that ginsenoside Rg3 could modulate L-, N-, and P/Q-type currents. In addition, ginsenoside Rg3 also proved to be an active component of ginseng actions on NMDA receptors in cultured hippocampal neurons. Application of ginsenoside Rg3 suppressed NMDA-induced [Ca2+]i increase an d-gated channels using fura-2-based digital imaging and patch-clamp techniques, respectively. These results suggest that the modulation of Ca2+ channels and NMDA receptors by ginsenoside Rg3 could be part of the pharmacological basis of ginseng actions in the
peripheral and central nervous systems.
among the 11 ginsenosides tested, produced the strongest inhibition on Ca2+ channel currents. Occlusion experiments using selective Ca2+ channel blockers revealed that ginsenoside Rg3 could modulate L-, N-, and P/Q-type currents. In addition, ginsenoside Rg3 also proved to be an active component of ginseng actions on NMDA receptors in cultured hippocampal neurons. Application of ginsenoside Rg3 suppressed NMDA-induced [Ca2+]i increase an d-gated channels using fura-2-based digital imaging and patch-clamp techniques, respectively. These results suggest that the modulation of Ca2+ channels and NMDA receptors by ginsenoside Rg3 could be part of the pharmacological basis of ginseng actions in the
peripheral and central nervous systems.
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