지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 1999.6
- 수록면
- 133 - 140 (8page)
이용수
초록· 키워드
오류제보하기
The effect of docosahexaenoic acid (DHA) on the memory loss was investigated in two different animal models of dementia (active and passive avoidance models). In the active avoidance retention performance, DHA was administered to experimental animals for 24 days and ibotenic acid, a neurotoxin known to cause destruction of cholinergic nerve terminals, was injected into the nucleus basalis meynert on the 12th day. In the passive avoidance retention performance, DHA was administered to experimental animals for 24 days and either ibotenic acid or scopolamine was injected 24 hours (ibotenic acid) or 30 min (scopolamine) before the experiment. All animals were tested for the active and passive avoidance by the shuttle box and the reflex system, acetylcholinesterase (AChE) activity, AChE distribution by histochemical staining, amyloid protein and synaptophysin distribution by immunohistochemical staining and the degree of lipid peroxidation in the brain. DHA did not have any effect on the inhibition of the active and passive avoidance induced by ibotenic acid. On the other hand, scopolamine-induced inhibition of passive avoidance was partially reversed by DHA, indicating the implication of DHA in potentiation of cholinergic transmission. No differences were observed in AChE activity, AChE distribution, amyloid protein deposition synaptophysin distribution and the degree of lipid peroxidation between DHA-treated and vehicle (10% corn oil)-treated groups. These results demonstrated that administration of DHA for 24 days did not have any effect on the memory loss induced by ibotenic acid whereas scopolamine-induced memory loss was partially reversed by DHA. The precise role of cholinergic transmission potentiating effect of DHA in term of improving memory and/or learning ability remains to be elucidated.
목차
ABSTRACT
Ⅰ. 서론
Ⅱ. 재료 및 방법
Ⅲ. 결과
Ⅳ. 고찰
참고문헌
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Effects of Docosahexaenoic Acid on Neurotransmission
Biomolecules & Therapeutics(구 응용약물학회지)
2012 .01
-
加味神仙不老丹이 ibotenic acid손상에 의해 유도된 치매 백서의 학습 및 기억장애에 미치는 영향
동의생리병리학회지
2002 .12
-
Docosahexaenoic acid가 전기충격성 뇌장애 마우스의 기억력 및 Acetylcholine량 변화에 미치는 영향
약학회지
1995 .01
-
The Efficiency of Deer Antler Herbal Acupuncture on Modulation and Prevention of IL-1 Mediated Activation in Rat Chondrocytes at a Receptor Level
대한침구의학회지
2006 .01
-
Treadmill Exercise Ameliorates Short-Term Memory Disturbance in Scopolamine-Induced Amnesia Rats
International Neurourology Journal
2014 .01
-
Scopolamine 유발 기억 손상 마우스에서 익모초의 효과
동의생리병리학회지
2020 .04
-
Ethyl Docosahexaenoate and Its Acidic Form Increase Bone Formation by Induction of Osteoblast Differentiation and Inhibition of Osteoclastogenesis
Biomolecules & Therapeutics(구 응용약물학회지)
2011 .01
-
Protective Effect of Omega-3 of Polyunsaturated Fatty Acid Docosahexaenoic Acid on the Organic Mercury-Induced Cytotoxicity in Cultured NIH3T3 Fibroblasts
대한의생명과학회지
2008 .09
-
Docosahexaenoic acid reduces adenosine triphosphate-induced calcium influx via inhibition of store-operated calcium channels and enhances baseline endothelial nitric oxide synthase phosphorylation in human endothelial cells
The Korean Journal of Physiology & Pharmacology
2019 .01
-
한약복합물 HT008-1의 인지기능 및 기억력 향상효과
대한본초학회지(본초분과학회지)
2007 .01
-
합환피의 인지 및 기억력 개선 효과에 대한 연구
동의생리병리학회지
2017 .10
-
합환피의 인지 및 기억력 개선 효과에 대한 연구
동의생리병리학회지
2017 .01
-
C-terminal Truncation Mutant of the Human ${\beta}_2$-adrenergic Receptor Expressed in E. coli as a Fusion Protein Retains Ligand Binding Affinity
The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmacology
1996 .01
-
Effect of Glycyrrhizic Acid on Scopolamine-Induced Cognitive Impairment in Mice
International Neurourology Journal
2020 .01
-
Forsythiaside, a Constituent of the Fruits of Forsythia suspense, Ameliorates Scopolamine-Induced Memory Impairment in Mice
Biomolecules & Therapeutics(구 응용약물학회지)
2009 .01
-
포공영 기원식물의 mouse 기억력 개선효과 비교
대한본초학회지(본초분과학회지)
2012 .01
-
기억력 감퇴모델에서 산사의 기억력 개선 효과에 관한 연구
대한본초학회지(본초분과학회지)
2009 .01
-
Scopolamine 유발 기억 손상 마우스 모델에서 국산 산사와 중국산 산사의 항건망 효과 비교
동의생리병리학회지
2018 .01
이 논문의 저자 정보
이 논문과 함께 이용한 논문
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2009-513-013746579