지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.10
- 수록면
- 270 - 276 (7page)
- DOI
- 10.15188/kjopp.2017.10.31.5.270
이용수
초록· 키워드
오류제보하기
The aim of this study was to investigate the effects of the water extract of Albizziae Cortex (AC) on the learning and memory impairments. AC was administered to normal mouse and scopolamine-injected amnesia mouse model. Passive avoidance test, Y-maze test, and Morris water maze test were conducted to confirm the cognitive-enhancing activities of AC. Acetylcholinesterase (AChE) activity and acetylcholine (Ach) content were measured after oral administration of AC. On the passive avoidance test, AC (200 mg/kg) significantly increased latency time and recovered scopolamine-impaired learning and memory in mice. In addition, AC (200 mg/kg) reduced Exploration time in target quadrant and reversed the scopolamine-induced cognitive impairments in the Y-maze test. Moreover, AC (200 mg/kg) increased exploration time in target quadrant and improved scopolamine-reduced escape latencies in the Morris water maze test. These effects were presented by regulatory effects of AC on AChE activity and Ach content. Taken together, AC increases cognitive-enhancing activities and ameliorates scopolamine-induced learning and memory impairment. AC might be a potential agent for prevention and treatment of amnesia and dementia.
목차
서론
재료 및 방법
결과
고찰
결론
References
참고문헌 (26)
참고문헌 신청
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[학술지(정기간행물)] - Nordberg A / 1996 / Pharmacological treatment of cognitive dysfunction in dementia disorders / Acta Neurologica Scandinavica 168 : 87 ~ 92
[학술지(정기간행물)] - Lemiere JJ. / 1999 / Treatment of Alzheimer's disease: an evaluation of cholinergic approach / Acta Neurol. Belg 99 : 96 ~ 106
[학술지(정기간행물)] - Kuhl DE / 1999 / In vivo mapping of cerebral acetylcholinesterase activity in aging and Alzheimer’ disease / Neurology 52 : 691 ~ 699
[학술지(정기간행물)] - Evans DA / 1989 / Prevalence of Alzheimer's disease in a community population of older persons. Higher than previously reported / JAMA 262 : 2551 ~ 2556
[학술지(정기간행물)] - Nordberg A / 1996 / Pharmacological treatment of cognitive dysfunction in dementia disorders / Acta Neurologica Scandinavica 168 : 87 ~ 92
[학술지(정기간행물)] - Lemiere JJ. / 1999 / Treatment of Alzheimer's disease: an evaluation of cholinergic approach / Acta Neurol. Belg 99 : 96 ~ 106
[학술지(정기간행물)] - Kuhl DE / 1999 / In vivo mapping of cerebral acetylcholinesterase activity in aging and Alzheimer’ disease / Neurology 52 : 691 ~ 699
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UCI(KEPA) : I410-ECN-0101-2018-519-001411142