지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2003.12
- 수록면
- 435 - 445 (11page)
이용수
초록· 키워드
오류제보하기
For many years, it has been recognized that some compounds in several foods have beneficial medicinal effects to health. Among these, flavonoids exhibit various physiological and pharmacological properties such as antioxidative, antibacterial, antimutagenic and anticancer activities. These polyphenolic compounds are found ubiquitously in foods of plant origins.
Green tea is one of the major sources of polyphenol compounds. Because of low toxicity, some of flavonoids are thought to have potential to be developed into a new class of prophylactic or therapeutic agents against various kinds of diseases. This study was performed to investigate the effects of green tea extract and polyphenols on the proliferation and activity of osteoblasts and generation of osteoclasts. Green tea extract increased the proliferation of osteoblasts at relatively low concentration (10-12 - 10-9 M). However, they inhibited the proliferation and viability of osteoblasts at higher concentrations (10-8 - 10-5 M). Green tea extract increased the alkaline phosphatase (ALP) activities of HOS cells. Green tea extract increased ALP activity of ROS17/2.8 cells at lower concentrations, and decreased it at higher concentrations. Green tea extract inhibited the generation of osteoclasts. Polyphenols, such as catechin, epicatechin and epigallocatechin gallate (EGCG), increased the proliferation of osteoblasts at lower concentrations. Epicatechin increased the ALP activities of osteoblasts at lower concentrations. Catechin inhibited the proliferation of HOS cells at higher concentration. However, it stimulated the proliferation of ROS17/2.8 cells. Higher concentrations of EGCG increased the ALP activities of HOS and ROS17 /2.8 cells. Polyphenols when treated with lower concentration, stimulated the generation of osteoclasts. However, catechin and EGCG inhibited the generation of osteoclasts at higher concentrations. Taken together, this result indicates that green tea extract and polyphenols, when used at appropriate concentrations, may stimulate the proliferation and activities of osteoblast, while inhibiting generation of osteoclasts. These compounds could be useful as prophylactic and therapeutic agents for many bone diseases which accompanies massive bone loss.
Green tea is one of the major sources of polyphenol compounds. Because of low toxicity, some of flavonoids are thought to have potential to be developed into a new class of prophylactic or therapeutic agents against various kinds of diseases. This study was performed to investigate the effects of green tea extract and polyphenols on the proliferation and activity of osteoblasts and generation of osteoclasts. Green tea extract increased the proliferation of osteoblasts at relatively low concentration (10-12 - 10-9 M). However, they inhibited the proliferation and viability of osteoblasts at higher concentrations (10-8 - 10-5 M). Green tea extract increased the alkaline phosphatase (ALP) activities of HOS cells. Green tea extract increased ALP activity of ROS17/2.8 cells at lower concentrations, and decreased it at higher concentrations. Green tea extract inhibited the generation of osteoclasts. Polyphenols, such as catechin, epicatechin and epigallocatechin gallate (EGCG), increased the proliferation of osteoblasts at lower concentrations. Epicatechin increased the ALP activities of osteoblasts at lower concentrations. Catechin inhibited the proliferation of HOS cells at higher concentration. However, it stimulated the proliferation of ROS17/2.8 cells. Higher concentrations of EGCG increased the ALP activities of HOS and ROS17 /2.8 cells. Polyphenols when treated with lower concentration, stimulated the generation of osteoclasts. However, catechin and EGCG inhibited the generation of osteoclasts at higher concentrations. Taken together, this result indicates that green tea extract and polyphenols, when used at appropriate concentrations, may stimulate the proliferation and activities of osteoblast, while inhibiting generation of osteoclasts. These compounds could be useful as prophylactic and therapeutic agents for many bone diseases which accompanies massive bone loss.
목차
1. 서론
2. 연구대상 및 연구방법
3. 연구결과
4. 총괄 및 고찰
5. 결론
참고문헌
ABSTRACT
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
체중감량 목적으로 사용되는 녹차추출물의 임상정보
한국임상약학회지
2018 .01
-
녹차에 의한 직업성 천식 및 비염 1예
천식 및 알레르기
2009 .01
-
Effects of Eucommiae Cortex on Osteoblast-like Cell Proliferation and Osteoclast Inhibition
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2003 .01
-
Modulation of adipogenesis and lipolysis by green tea in 3T3- Ll adipocytes
한국응용약물학회 추계학술발표논문집
2003 .01
-
녹차 추출물 중 카테킨 성분 농도에 따른 항균활성 비교 연구
동의생리병리학회지
2005 .10
-
하이드록시아파타이트 지지체의 표면 처리 방법에 따른 골아세포의 성장
대한성형외과학회지
2010 .01
-
패턴인식법에 의한 시판 녹차의 산지 및 채엽시기 추정
약학회지
2009 .01
-
Effects of Achyranthes Radix Extracts on Osteoblasts and Osteocalsts
International Journal of Oral Biology
2005 .01
-
녹차 분말과 카테킨의 농도에 따른 항산화력 비교 분석
동의생리병리학회지
2005 .12
-
Growth inhibition and induction of apoptosis in cervical cancer cell linesby green tea polyphenols
Obstetrics & Gynecology Science
2002 .01
-
Anti-Proliferative Activity of Green Tea Catechin on Vascular Smooth Muscle Cells
대한약학회 학술대회
2002 .01
-
Inhibitiory effect of green tea extract on $A\beta$-induced PC12 cell death
대한약학회 학술대회
2003 .01
-
TiO₂ 나노튜브의 직경 및 길이에 따른 조골세포의 흡착 및 골형성능 효과
대한치과재료학회지
2010 .06
-
녹차 분말과 카테킨의 농도에 따른 항산화력 비교 분석
동의생리병리학회지
2005 .01
-
Endothelin-1이 HOS 세포의 증식과 활성에 미치는 영향
Journal of Oral Medicine and Pain
2001 .12
-
인체 조골세포 MG-63 세포증식에 미치는 생약초 추출물의 효과
Oral Biology Research
2011 .01
-
Oxidative DNA damage by Ethanol Extract of Green Tea
한국환경성돌연변이·발암원학회지
2005 .06
-
A2B Adenosine Receptor Stimulation Down-regulates M-CSF-mediated Osteoclast Proliferation
대한의생명과학회지
2017 .09
이 논문의 저자 정보
이 논문과 함께 이용한 논문
RANKL에 의해 유도되는 파골세포 분화에 대한 시금치 추출물의 영향
김동규
,
김미혜
,
강민정
외 1명
한국식품영양과학회지
2015
.04
Cumin(Cuminum cymium L.) seed로부터 정제한 2-hydroxyethyl-β-undecenate의 항치주염 효과의 효소학적 평가
류일환
,
강은주
,
이갑상
외 1명
한국식품과학회지
2007
.12
아보카도 과육, 과피 및 씨 추출물이 조골세포 분화 및 파골세포 형성에 미치는 영향
김미진
,
임남경
,
유미희
외 2명
한국식품영양과학회지
2011
.07
Chitosan이 구취 관련 구강 세균의 증식에 미치는 억제효과
김도윤
,
신금백
,
장기완
Journal of Oral Medicine and Pain
2002
.03
녹차 추출물 중 카테킨 성분 농도에 따른 항균활성 비교 연구
최경민
,
윤용갑
,
강경화
외 5명
동의생리병리학회지
2005
.10
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2009-515-013756875