지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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For a long time Rhus verniciflua Stokes (RVS) has been traditionally used as a herbal plant in Asia. In this study, we have investigated the effect of acetone extract of Rhus verniciflua Stokes (RVSE) and fisetin, a component of RVSE, on DNA damage response in NIH3T3 cells. Exposure of cells to UVB light (200 J/㎡) and postincubation in growth medium for 48 hr resulted in a decrease of cell viability to about 10-20% of nontreated control. Addition of various concentrations of RVSE in the postincubation medium, however, significantly increased the cell viability as compared with the values expected. The genotoxicity-decreasing effect was also demonstrated in cells exposed to UVB light and incubated in medium containing fisetin. The genotoxicity-decreasing effect of RVSE and fisetin was further demonstrated by various analyses including cell morphology studies, trypan blue exclusion assay and DAPI staining. By Annexin V binding analysis, RVSE and fisetin were shown to decrease the early apoptosis induced by UVB exposure. These results suggest the RVSE contain components that either increase the DNA repair or decrease the apoptosis in UVB-exposed cells.
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Abstract
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참고문헌
참고문헌 (29)
참고문헌 신청
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Guengerich, F. P. 1989. Roles of cytochrome P-450 enzymes in chemical cacinogenesis and cancer chemotherapy. Cancer Res. 48, 2946-2954.
Harborne, J. B. and C. A. Williams. 2000. Advances in flavonoids research since 1992. Phytochemisty 55, 481-504.
Hayatsu, H., N. Inada, T. Kakutani, S. Arimoto, T. Negishi, K. Mori, T. Okuda and I. Sakata. 1992. Suppression of genotoxicity of carcinogens by (-)-epigallocatechin gallate. Prevent. Med. 21, 370-376.
Hwang, S. J., J. Y. Cha, S. G. Park, G. J. Joe, H. M. Kim, H. B. Moon, S. J. Jeong, J. S. Lee, D. H. Shin, S. R. Ko and J. K. Park. 2002. Diol and triol type ginseng saponins potentiate the apoptosis of NIH3T3 cells exposed to MMS. Toxicol. Appl. Pharmaco
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NIH3T3 세포에서 UVB에 의한 세포고사와 DNA 단사절단에 미치는 fisetin의 효과
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UCI(KEPA) : I410-ECN-0101-2009-470-015374651