지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Tuberculosis is the leading infectious disease in the world. It is urgent to develop new vaccine and treating drugs. Besides vaccines, we want to know the effects of regular swim training on TB infection in the mouse model. This study was designed to examine the effects of regular swim training on lung and spleen TB counts and INF-γ activity in the trained mice at different temperature. The trained mice underwent a 10-wk endurance swim training (5 times/wk) in water at 29～33℃ (WWG) and 21～23℃ (CWG) for 60 min. And they were divided into 3 groups according to the regular swim training (CG; control, WWG; warm water group, and CWG; cold water group). Mice were challenged by aerosol infection with M. tuberculosis H37Rv using an inhalation device (Glas-Col, Terre Haute, Ind.) calibrated to deliver bacteria into lungs. Three weeks after immunization, the mice were challenged. Four weeks after challenge, the mice were sacrificed and the numbers of viable bacteria in lung and spleen were determined by plating serial dilution of whole organ homogenates on nutrient Middlebrook 7H11 agar (Difco, Detroit, MI). Colonies were counted after four weeks incubation at 37℃. All data were expressed as mean, standard deviation by using SPSS package program (win 10.0). The result through the statistical analysis of this data were summarized as follows; In the weight changes, there were significant differences among CG, WWG, and CWG following the swim training at different temperature, and CWG was the lowest. In the change of INF-γ following the swim training, there were significant differences (p＜.05) among CG, WWG, and CWG after stimulated with media and CFP. In MTB counts, there were significant differences (p＜.05) between CG and WWG in the lung. And also there were significant differences (p＜.05) among CG, WWG, and CWG. These results suggest that regular swim training suppress Th1 immune response caused by decreased INF-γ level in the WWG, Also For the WWG, highly increased level of TB counts appear in the lung and spleen compare to CG.
목차
Abstract
연구 방법
결과
고찰
요약
참고문헌
참고문헌 (21)
참고문헌 신청
Public Health Laboratory Service, Disease Notifiable under the Public Health Act 1984. Annual totals 1991-2001 shows a steady increase in incidence from 5436 in 1992 to 6572 in 2001. PHLS website at http://www.phls.co.uk.
Harris, A. and Martin, R. 2004. The exercise of public health powers in an era of human rights: the particular problems of tuberculosis. Public Health. 118, 313-322.
Nagami, P. and Yoshikawa, T. T. 1983. Tuberculosis in the geriatric patient. Journal of the American Geriatric Society. 31, 356-363.
Marchal, G. 1997. Pathophysiology and immunology of tuberculosis. Rev. Mal. Respir. Dec.14 Suppl. 5, S19-26.
Yoshikawa, T. T. 1994. The challenge and unique aspects of tuberculosis in older patients. Infectious Disease in Clinical Practice. 3, 62-66.
Nagami, P. and Yoshikawa, T. T. 1983. Tuberculosis in the geriatric patient. Journal of the American Geriatric Society. 31, 356-363.
Marchal, G. 1997. Pathophysiology and immunology of tuberculosis. Rev. Mal. Respir. Dec.14 Suppl. 5, S19-26.
Yoshikawa, T. T. 1994. The challenge and unique aspects of tuberculosis in older patients. Infectious Disease in Clinical Practice. 3, 62-66.
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UCI(KEPA) : I410-ECN-0101-2009-470-015375476