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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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This article would include a comprehensive review of biological markers in schizophrenia. A marker is measurable variation in structure, function, or performance that is associated with an illness. There are at least two important kinds of markers in psychiatry. The first, state marker is found in at least a subgroup of acutely ill patients. The second kind, the trait marker is genetically controlled, seen during illness, before symptom first appear, and between episodes, and is also prevalent in close relatives. Finding biological markers for schizophrenia have been rendered particularly difficult mainly because of three factors : diagnostic uncertainty ; the possibility that schizophrenia is caused by the concerted action of more than one gene ; unlike other organs, central nervous system has seemed nearly impenetrable to researchers. Recent technological advances has made possible the exploration of numerous aspects of brain function and structure, and has permitted the development of biological measures that could potentially serve as markers of schizophrenia. The search for biological markers has extended through a wide range of disciplines, including psychophysiology, neurochemistry, neuroendocrinology, psychoimmunology, neuropathology, psychiatric genetics, neuropsychology, and brain imaging. However, despite dramatic progress in these research areas, biological markers with sufficient specificity, sensitivity and replicability to be used in clinical evaluation have not yet been identified. Nevertheless, there are several candidates. In this review, we describe characteristics and research methods of putative biological markers, and evaluate both their promise and their limitations, and discuss potential utility in clarifying diagnostic, genetic, therapeutic, and prognostic issues in schizophrenia.
목차
영어 초록
서론
생물학적 표지의 특징
표지연구의 방법과 문제점
정신분열증의 가능성 있는 표지들
결론
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UCI(KEPA) : I410-ECN-0101-2009-513-017198935