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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 27 - 36 (10page)
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ObjectiveaaClassifying mental disorders on the basis of objective makers might clarify their aetiology, help in making the diagnosis, identify “at risk” individuals, determine the severity of mental illness, and predict the course of the disorder. This study aims to review biological and clinical markers of panic disorder (PD). MethodsaaA computerized search was carried out in PubMed and Science Direct using the key words: “marker/biomarker/clinical marker/neurobiology/staging” combined using Boolean AND operator with “panic.” In addition, the reference lists from existing reviews and from the articles retrieved were inspected. Only English language papers published in peer-reviewed journals were included. ResultsaaStructural changes in the amygdala, hippocampus, cerebral blood level in the left occipital cortex, serotonin 5-TH and noradrenergic systems activation, aberrant respiratory regulation, hearth rate variability, blood cells and peripheral blood stem cells, hypothalamic– pituitary–adrenal axis dysregulation were identified as potential candidate biomarkers of PD. Staging was identified as clinical marker of PD. According to the staging model, PD is described as follows: prodromal phase (stage 1); acute phase (stage 2); panic attacks (stage 3); chronic phase (stage 4). ConclusionaaThe clinical utility, sensitivity, specificity, and the predictive value of biomarkers for PD is still questionable. The staging model of PD might be a valid susceptibility, diagnostic, prognostic, and predictive marker of PD. A possible longitudinal model of biological and clinical markers of PD is proposed.
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참고문헌 (104)
참고문헌 신청
EKalia M / 2015 / Biomarkers of psychiatric diseases : current status and future prospects / Metabolism 64:S11~S15
Scarr E / 2015 / Biomarkers for psychiatry : the journey from fantasy to fact, a report of the 2013 CINP think tank / Int J Neuropsychopharmacol 18:1~9
2001 / Biomarkers Definitions Working Group Biomarkers and surrogate endpoints / Clin Pharmacol Ther 69:89~95
Venkatasubramanian G / 2016 / Biomarkers in psychiatry-a critique / Ann Neurosci 23:3~5
Macaluso M / 2012 / How biomarkers will change psychiatry: from clinical trials to practice. Part I, Introduction / J Psychiatr Pract 18:118~121
Scarr E / 2015 / Biomarkers for psychiatry : the journey from fantasy to fact, a report of the 2013 CINP think tank / Int J Neuropsychopharmacol 18:1~9
2001 / Biomarkers Definitions Working Group Biomarkers and surrogate endpoints / Clin Pharmacol Ther 69:89~95
Venkatasubramanian G / 2016 / Biomarkers in psychiatry-a critique / Ann Neurosci 23:3~5
Macaluso M / 2012 / How biomarkers will change psychiatry: from clinical trials to practice. Part I, Introduction / J Psychiatr Pract 18:118~121
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