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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Objectives : Previous findings on nociception modulatory effect of testosterone were controversial. In this study, androgen receptor antagonist flutamide was used to reveal testosterone effect on baseline nociceptive sensitivity and stress-induced antinociception in male mice.
Methods : Experiments consist 3 parts: 1) tail flick latency(TFL, sec, 52±1℃) was measured before and 30 minutes after intraperitoneal injection of flutamide 150, 100, 50㎎/㎏ or vehicle(N=15 for each group); 2) TFL was measured before and after serial injection of LHRH antagonist antide(1㎎/㎏, ip), and 30 minutes after flutamide(100㎎/㎏, ip) or vehicle; 3) With pretreatment of flutamide(100㎎/㎏, ip) or vehicle(N=15 for each group), TFL was measured before and after 5 minutes of forced-swim in cold water(15±1℃).
Results;
1. TFL was significantly elongated(hypoalgesic) in the flutamide 100 and 50㎎/㎏ groups. TFL of flutamide 150㎎/㎏ group was significantly longer than 50㎎/㎏ group.
2. Though pretreatment with antide itself did not make any change in TFL, it blocked antinociceptive effect of flutamide. TFL was elongated by serial injections in both flutamide and control group.
3. TFL was elongated by FS in both flutamide and control group. FS-induced elongation of TFL was significantly more prominent in flutamide group.
Conclusions : From these results, it is suggested flutamide has antinociceptive effect on baseline TFL and potentiates FS-induced antinociception.
Methods : Experiments consist 3 parts: 1) tail flick latency(TFL, sec, 52±1℃) was measured before and 30 minutes after intraperitoneal injection of flutamide 150, 100, 50㎎/㎏ or vehicle(N=15 for each group); 2) TFL was measured before and after serial injection of LHRH antagonist antide(1㎎/㎏, ip), and 30 minutes after flutamide(100㎎/㎏, ip) or vehicle; 3) With pretreatment of flutamide(100㎎/㎏, ip) or vehicle(N=15 for each group), TFL was measured before and after 5 minutes of forced-swim in cold water(15±1℃).
Results;
1. TFL was significantly elongated(hypoalgesic) in the flutamide 100 and 50㎎/㎏ groups. TFL of flutamide 150㎎/㎏ group was significantly longer than 50㎎/㎏ group.
2. Though pretreatment with antide itself did not make any change in TFL, it blocked antinociceptive effect of flutamide. TFL was elongated by serial injections in both flutamide and control group.
3. TFL was elongated by FS in both flutamide and control group. FS-induced elongation of TFL was significantly more prominent in flutamide group.
Conclusions : From these results, it is suggested flutamide has antinociceptive effect on baseline TFL and potentiates FS-induced antinociception.
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UCI(KEPA) : I410-ECN-0101-2009-513-017216330