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자료유형
학술저널
저자정보
저널정보
고려인삼학회 Journal of Ginseng Research Journal of Ginseng Research Vol.30 No.3
발행연도
2006.9
수록면
106 - 111 (6page)

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초록· 키워드

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Adverse changes in individual’s biochemistry under heavy metal stress are directly linked with its metabolic activity and health status. The present investigation highlights the differences in protecting role of Panax ginseng extract against mercuric chloride induced alterations in serum proteins. The assessment was based on dividing fifty albino rats into two sets, one for acute and the other for sub-acute study. All the sets had five groups with five albino rats in each i.e. control group, mercuric chloride treated group, Panax ginseng extract treated group, mercuric chloride followed by Panax ginseng extract treated group and Panax ginseng extract followed by mercuric chloride treated group. Mercuric chloride was given orally 0.926 ㎎/㎏ body weight for acute set and 0.044 ㎎/㎏ body weight for sub-acute set after LD50 (9.26 ㎎/㎏ body weight) determination by probitt analysis. 10 ㎎/㎏ body weight Panax ginseng extract was given in both acute and sub-acute sets after incorporating safety trials. The control group received tween-20 and distilled water only. The result exhibited significantly reduction (P<0.01) in serum protein, albumin and globulin following mercuric chloride intoxication whereas significant (P<0.01) enhancement in other groups with Panax ginseng extract as an ingredient confirming its protective role. All serum samples were also electrophoresed in 10% SDS with standard marker using discontinuous buffering system. Gradual disappearance of alpha-2 and beta-1 globulin bands from electrophoretic pattern was observed, while a single sharp band was observed between beta-2 and gamma globulin in serum protein pattern of acutely mercuric chloride treated rats. However, this band could not be visualized in sub-acute studies. Panax ginseng extract exhibits a better protection after acute intoxication.

목차

Abstract
INTRODUCTION
MATERIAL AND METHODS
RESULTS & DISCUSSION
REFERENCES

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