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자료유형
학술저널
저자정보
저널정보
한국환경보건학회 한국환경보건학회지 한국환경보건학회지 제34권 제2호
발행연도
2008.1
수록면
161 - 169 (9page)

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이 논문의 연구 히스토리 (2)

2008

유기수은 노출로 인한 흰쥐 태자골격성장 지연에 대한 마늘의 보호효과
이진헌 ,  박경렬 ,  김대선 한국환경보건학회지 2008.01 학술저널

2006

유기수은의 노출이 흰쥐의 태자성장에 미치는 영향 연구
이진헌 한국보건교육건강증진학회 학술대회 발표논문집 2006.11 학술대회자료

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The purpose of this study was to evaluate the protective effects of Korean garlic juice against the toxicity of methyl mercuric chloride(MMC) about the fetal ossification in pregnant Fischer 344 rats, based on the theory and information that neutral amino acids in garlic juice have protective effects against mercury poisoning. We orally treated the 20 mg MMC/kg body wt. and 0.5 and 1.0 garlic juice/kg body wt. on the 7th day of gestation, and extract fetus from the dams on 20th day of gestation. And the fetal bones were stained and measured. The results obtained are as follows : 1. Fetal body weights, body lengths, and head length were significantly decreased as much as 23.5%, 21.3%, 15.5% in 20mg/ wt kg methyl mercuric chloride groups (p<0.05). But in garlic treated groups, they were almost similar with controls. 2. The ossification centers were significantly decreased as much as 35.1% in pelvic phalanges, 53.5% in pectoral phalanges, 74.1% in ternebrae, 76.2% in tail of 20 mg/wt kg methyl mercuric chloride groups (p<0.05). But in garlic treated groups, they were significantly increased as much as 81.2~88.7% and 94.8~98.9% of controls. 3. The ossified pectoral girdles were significantly decreased as much as 66.6% in clavicle, 74.2~87.4% in the others of 20mg/wt kg methyl mercuric chloride groups (p<0.05). But in garlic treated groups, they were significantly increased as much as 81.2~88.7% and 94.8~98.9% of controls. 4. The ossified pelvic girdles were significantly decreased as much as 57.1% and 56.1% in 2 ischium, 67.2~81.7% in metacarpals of 20 mg/wt kg methyl mercuric chloride groups (p<0.05). But in garlic treated groups, they were significantly increased as much as 67.0~85.6% and 90.1~98.7% of controls. 5. The ossified terenebrae were significantly decreased as much as 0.0% in 5th, 54.1% in 2th, 83.9% in 2nd, 75.0% in 3rd, 72.7% in 4th, 79.8% in 6th of 20 mg/wt kg methyl mercuric chloride groups (p<0.05). But in garlic treated groups, they were significantly increased as much as 29.5~55.1% and 54.5~84.0% of controls. 6. The ossified ribs were significantly decreased as much as 8.3~18.0% in 20 mg/wt kg methyl mercuric chloride groups (p<0.05). But in garlic treated groups, they were significantly increased as much as 87.1~93.5% and 96.3~99.7% of controls. In conclusion, Korean garlic juice significantly protected against the toxicity of MMC about the fetal ossification in pregnant rats.
#methyl mercuric chloride #MMC) #garlic juice #ossification

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참고문헌 (25)

참고문헌 신청
A.O.A.C. / 1984 / Official method of analysis, 14th edition / Association of Official Analytical Chemists : 878 ~ 880 google schola Amin-Zaki, L. / 1979 / Prenatal methylmercury poisoning : Clinical observation over five years / Am J. Dis. Child 133 : 172 ~ google schola Baker, H. J. / 1979 / Selected normative data, Appendix I in The laboratory rats / Academic Press : 412 ~ 413 google schola Calabrese, E. J. / 1980 / Nutrition and Environmental Health,The influence of nutritional status on pollutant toxicity and carcinogenicity / 학회지명 1 : 519 ~ 522 google schola Curle, D. C. / 1987 / In vivo evaluation of teratogenesis and cytogenetic changes following methylmercuric chloride treatment / The Anatomical Record 219 : 289 ~ 295 google schola

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