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논문 기본 정보
- 자료유형
- 학술대회자료
- 저자정보
- 발행연도
- 2006.5
- 수록면
- 83 - 88 (6page)
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In this study we examined the potential for the synergistic augmentation of the activity of inflammatory mouse peritoneal macrophages by stimulation with RGAP combined with IFN-γ. The moderate augmentative effect induced by preincubation with RGAP was observed in the production of IL-1, IL-6 and NO but not TNF-α. In addition, IFN-γ had a low activating effect. Following preincubation with both RGAP A and IFN-γ, a marked enhancement of secretory activity and tumoricidal activity was noted in mouse peritoneal macrophages. Treatment of peritoneal macrophage with combination increased the generation of IL-1, IL-6, TNF-α and NO, whereas the production of reactive oxygen species were not altered. These results demonstrate the synergistic effects on macrophage function of RGAP in combination with IFN-γ and suggest that the ability of IFN-γ to prime macrophages to produce secretory molecules in response to RGAP may have implications for immunotherapy with this combination.
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영어 초록
1. 서론
2. 재료 및 실험 방법
3. 결과 및 고찰
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UCI(KEPA) : I410-ECN-0101-2009-524-017426633