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자료유형
학술저널
저자정보
Du, Xiao Fei (Department of Pharmacology, Shenyang Pharmaceutical University) Jiang, Cheng Zhe (Department of Hygienic Chemistry and Kyung Hee East-West Pharmaceutical Research Institute, College of Pharmacy, Kyung Hee University) Wu, Chun Fu (Department of Pharmacology, Shenyang Pharmaceutical University) Won, Eun-Kyung (Department of Hygienic Chemistry and Kyung Hee East-West Pharmaceutical Research Institute, College of Pharmacy, Kyung Hee University) Choung, Se-Young (Department of Hygienic Chemistry and Kyung Hee East-West Pharmaceutical Research Institute, College of Pharmacy, Kyung Hee University)
저널정보
대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 제31권 제9호
발행연도
2008.1
수록면
1,153 - 1,159 (7page)

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We investigated the synergistic effect of combined treatment with red ginseng acidic polysaccharide (RGAP) from Panax ginseng C.A. Meyer and pidotimod in cyclophosphamide-treated mice. The combination of pidotimod and RGAP restored concanavalin A-induced splenic T cell proliferation and LPS-stimulated B cell proliferation significantly. The production of nitric oxide from peritoneal macrophages was increased by the combinations. NK cell activity was increased by RGAP alone or in combination with pidotimod. A synergistic increase in the level of serum IL-12 and interferongamm was observed when the combination of the two was used. RGAP alone or in combination with pidotimod modulated the level of serum C-reactive protein to a near-normal level. These results indicate that combinations of pidotimod and RGAP are synergistic and suggest that combination therapy using pidotimod and RGAP for improving immune activity may provide an additional benefit over the use of the two drugs by themselves.

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