지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2006.12
- 수록면
- 315 - 322 (8page)
이용수
초록· 키워드
오류제보하기
TALP-32 is highly basic protein with a molecular weight of 32 kDa purified from human term placenta. Some basic proteins such as defensins and cecropins are known to induce cell death by increasing membrane permeability and some of them are under development as an anticancer drug especially targeting multi-drug resistant cancers. Therefore, we investigated cytotoxic effect and mechanism of TALP-32. When HeLa cell was incubated with TALP-32, cytotoxicity was increased in time and dose dependent manner. As time goes by, HeLa cells became round and plasma membrane was ruptured. Increase of plasma membrane permeability was determined with LDH release assay. Also in transmission electron microscopy, typical morphology of necrotic cell death, such as cell swelling and intracellular organelle disruption was observed, but DNA fragmentation and caspase activation was not. And necrotic cell death was determined with Annexin V/PI staining. The cytotoxicity of TALP-32 was minimal and decreased on RBC and Hep3B respectively. These data suggests that TALP-32 induces necrosis on rapidly growing cells but not on slowly growing cells implicating the possibility of its development of anticancer peptide drug.
목차
ABSTRACT
서론
실험재료 및 방법
결과
고찰
감사의 글
참고문헌
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Glucose와 Phosphate가 제거된 M-TALP 배지에서의 난구세포 공배양에 의한 임신율 향상에 관한 연구
대한불임학회잡지
1999 .01
-
Apoptosis Induction, Cell Cycle Arrest and in Vitro Anticancer Activity of Gonothalamin in a Cancer Cell Lines
Asian Pacific journal of cancer prevention : APJCP
2012 .01
-
Soybean Peptides Induce Apoptosis in HeLa Cells by Increasing Oxidative Stress
대한의생명과학회지
2015 .06
-
Overexpression of p73 Enhances Cisplatin-Induced Apoptosis in HeLa Cells
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2006 .01
-
Celecoxib, a COX-2 Selective Inhibitor, Induces Cell Cycle Arrest at the G2/M Phase in HeLa Cervical Cancer Cells
Asian Pacific journal of cancer prevention : APJCP
2016 .01
-
Betaine Effects on Morphology, Proliferation, and p53-induced Apoptosis of HeLa Cervical Carcinoma Cells in Vitro
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Cannabidiol Induces Cytotoxicity and Cell Death via Apoptotic Pathway in Cancer Cell Lines
Biomolecules & Therapeutics(구 응용약물학회지)
2008 .01
-
PD98059 Induces the Apoptosis of Human Cervical Cancer Cells by Regulating the Expression of Bcl2 and ERK2
대한의생명과학회지
2011 .12
-
Harnessing of Programmed Necrosis for Fighting against Cancers
Biomolecules & Therapeutics(구 응용약물학회지)
2014 .01
-
Cyclamen Exerts Cytotoxicity in Solid Tumor Cell Lines: a Step Toward New Anticancer Agents?
Asian Pacific journal of cancer prevention : APJCP
2013 .01
-
Effects of antioxidants and an anticancer drug against H2O2-induced cell injury
대한약학회 학술대회
2000 .01
-
The Effects of Peroxiredoxin Ⅲ on Human HeLa Cell Proliferation
Immune Network
2003 .12
이 논문의 저자 정보
이 논문과 함께 이용한 논문
S-allylcysteine의 자궁경부암세포주 HeLa에 대한 세포증식 억제효과
김현희
,
민계식
생명과학회지
2015
.04
전도성 고분자 나노임프린트 패턴 상의 HeLa 세포 배양
안준형
,
박경숙
,
이수옥
외 4명
대한기계학회 논문집 B권
2017
.01
AFM를 이용한 환경오염물질의 HeLa cell 표면독성 연구
이시원
,
최진희
대한환경공학회 학술발표논문집
2006
.12
Automated Cell Counting Method for HeLa Cells Image based on Cell Membrane Extraction and Back-tracking Algorithm
경민영
,
박정호
,
김명구
외 2명
Journal of KIISE
2015
.10
넓패 추출물이 HeLa 자궁암세포의 세포사멸에 미치는 영향
조병옥
,
류형원
,
소양강
외 4명
한국식품영양과학회지
2012
.07
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2009-513-017647433