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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2006.12
- 수록면
- 361 - 370 (10page)
이용수
초록· 키워드
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To evaluate an effect of pathological liver damage on the conjugation of cyclohexane metabolites, rats were pretreated with 50% CCl₄ dissolved in olive oil (0.1 ㎖/100 g body weight) 10 or 17 times intraperitoneally at intervals of every other day. On the basis of liver function, the animals pretreated with CCl₄ 10 times were identified as acutely liver damaged ones and the animals pretreated with CCl₄ 17 times were identified as severly liver damaged ones. To these liver damaged animals, cyclohexane (a single dose of 1.56 g/㎏ body weight, i.p.) was administered at 48 hr after the last injection of CCl₄. The rats were sacrificed at 4 or 8 hr after injection of cyclohexane. The cyclohexane metabolites, cyclohexanol (CH-ol), cyclohexane-1,2-diol (CH-1,2-diol), cyclohexane-1,4-diol (CH-1,4-diol), and their glucuronyl conjugates and cyclohexanone were detected in the urine of cyclohexane treated rats. The urinary concentration of cyclohexane metabolites was generally more increased in liver damaged animals than normal ones, and the increasing rate was higher in CCl₄ 17 times injected rats than 10 times injected ones. And liver damaged rats, especially CCl₄ 17 times treated ones, had an enhanced ability of glucuronyl conjugation to CH-ol analogues compared with normal group. Futhermore, CH-1,2 and 1,4-diol were all conjugated with glucuronic acid in CCl4 17 times injected animals. On the other hand, the increasing rate of activities of hepatic cytochrome P450 dependent aniline hydroxylase, alcohol dehydrogenase and urine diphosphate glucuronyl transferase was higher in 17 times CCl₄-treated rats compared with normal and CCl₄ 10 times injected animals. Taken all together, it is assumed that an increased urinary excretion amount of cyclohexane metabolites in liver damaged rats might be caused by an increase in the activities of cyclohexane metabolizing enzymes. And enhanced conjugating ability of CH-ol in liver damaged animals and novel finding of conjugating form of CH-1,2 and 1,4-diol might be caused by increase in the activity of hepatic diphosphouridine glucuronyltransferase.
목차
서론
재료 및 방법
결과
고찰
REFERENCES
참고문헌 (48)
참고문헌 신청
1. [학술지(정기간행물)] - J,Bao / 1997 / Simultaneous determination of cyclohexene oxide and its metabolites in rat plasma and urine by gas chromatography / J Chromatogr B. 696 : 59 ~ 68
2. [단행본] - HU,Bergmeyer / 1974 / Methods of enzymatic analysis. Vol. 2 / Academic Press, NY, USA. : 428 ~ 429
3. [단행본] - AM,Bernard / 1989 / Evaluation of the subacute nephrotoxicity of cyclohexane and other industrial solvents in the female Sprague-Dawley rat / Toxicol Lett. 45 : 271 ~ 280
4. [단행본] - OA,Bessey / 1946 / A method for the rapid determination of alkaline phosphatase with five cubic milimeters of serum / J Biol Chem. 164 : 321 ~ 337
5. [단행본] - WR,Bidlack / 1982 / Multiple drug metabolism: p-nitroanisole reversal of acetone enhanced aniline hydroxylation / Biochem Pharmacol. 31 : 311 ~ 317
2. [단행본] - HU,Bergmeyer / 1974 / Methods of enzymatic analysis. Vol. 2 / Academic Press, NY, USA. : 428 ~ 429
3. [단행본] - AM,Bernard / 1989 / Evaluation of the subacute nephrotoxicity of cyclohexane and other industrial solvents in the female Sprague-Dawley rat / Toxicol Lett. 45 : 271 ~ 280
4. [단행본] - OA,Bessey / 1946 / A method for the rapid determination of alkaline phosphatase with five cubic milimeters of serum / J Biol Chem. 164 : 321 ~ 337
5. [단행본] - WR,Bidlack / 1982 / Multiple drug metabolism: p-nitroanisole reversal of acetone enhanced aniline hydroxylation / Biochem Pharmacol. 31 : 311 ~ 317
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G009의 간 보호작용에 관한 연구
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건율제조탕이 CCl로 유발(誘發)된 간손상(肝損傷) 백서(白鼠)에 미치는 영향(影響)
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UCI(KEPA) : I410-ECN-0101-2009-510-017673949