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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2006.9
- 수록면
- 241 - 247 (7page)
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초록· 키워드
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To evaluate an effect of pathological liver damage on the cyclohexane (CH) metabolism, rats were pretreated with 50% carbon tetrachloride (CClG<SUB>4</SUB>) dissolved in olive oil (0.1 ml/100g body weight) 10 or 17 times intraperitoneally at intervals of every other day. To these liver damaged animals, CH (a single dose of 1.56 g/kg body weight, i.p.) was administered at 48 hr after the last injection of CCl<SUB>4</SUB>. The CH metabolites; cyclohexanol (CH-ol), cyclohexane-1,2-diol (CH-1,2-diol) and cyclohexane-1,4-diol (CH-1,4-diol) and cyclohexanone (CH-one) were detected in the urine of CH treated rats. After CH treatment, the serum levels of CH-ol and CH-one were remarkably increased at 4 hr and then decreased at 8 hr in normal group. Whereas in liver damaged rats, these CH metabolites were higher at 8 hr than at 4 hr. The excretion rate of CH metabolites from serum into urine was more decreased in liver damaged animals than normal group, with the levels of excretion rate being lower in CCl<SUB>4</SUB> 17 times injected animals than 10 times injected ones. It was interesting that the urinary concentration of CH metabolites was generally more increased in liver damaged animals than normal ones, and the increasing rate was higher in CCl<SUB>4</SUB> 17 times injected rats than 10 times injected ones. Taken all together, it is assumed that reduced urinary excretion rate of CH metabolites in liver damaged rats might be resulted from deteriorated hepatic and renal blood flow, and an increased urinary excretion amount of CH metabolites in liver damaged rats might be caused by reduced expiration amount of the metabolites due to lung damage.
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재료 및 방법
결과
고찰
REFERENCES
참고문헌 (31)
참고문헌 신청
[학술지(정기간행물)] - J,Bao / 1997 / Simultaneous determination of cyclohexene oxide and its metabolites in rat plasma and urine by gas chromatography / J Chromatography B. 696 : 59 ~ 68
[학술지(정기간행물)] - AM,Bernard / 1989 / Evaluation of the subacute nephrotoxicity of cyclohexane and other iindustrial solvents in the female Sprague-Dawley ratn / Toxicol Lett. 45 : 271 ~ 280
[학술지(정기간행물)] - AR,Butler / 1975 / The jaffe reaction. Identification of the coloured species / Clin Chem Acta. 59 : 227 ~ 232
[학술지(정기간행물)] - SE,Cha / 1998 / Effect of hepatic damage on the toluene metabolism in CCl4 pretreated rats / J Toxicol Pub Health 14 : 321 ~ 328
[단행본] - MJ,Ellenhorn / 1988 / Medical toxicology / Elsevier.NY, USA
[학술지(정기간행물)] - AM,Bernard / 1989 / Evaluation of the subacute nephrotoxicity of cyclohexane and other iindustrial solvents in the female Sprague-Dawley ratn / Toxicol Lett. 45 : 271 ~ 280
[학술지(정기간행물)] - AR,Butler / 1975 / The jaffe reaction. Identification of the coloured species / Clin Chem Acta. 59 : 227 ~ 232
[학술지(정기간행물)] - SE,Cha / 1998 / Effect of hepatic damage on the toluene metabolism in CCl4 pretreated rats / J Toxicol Pub Health 14 : 321 ~ 328
[단행본] - MJ,Ellenhorn / 1988 / Medical toxicology / Elsevier.NY, USA
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