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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국식품영양과학회 Journal of Food Science and Nutrition Journal of Food Science and Nutrition Vol.12 No.1
- 발행연도
- 2007.3
- 수록면
- 11 - 15 (5page)
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초록· 키워드
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This study was conducted to evaluate the influence of diets containing genistein and soy extract on the growth of MDA-MB-231 cells implanted into female Balb/c mice. Four-week-old female athymic nude mice (Balb/c) were acclimated to an AIN-93G control diet for 1 week and then injected MDA-MB-231 cells (1×10?/site) and were continued on the on AIN-93G control diet. Five weeks after injecting the MDA-MB-231 cells (1×10?/site), two experimental groups were assigned to diets containing genistein (750 ㎍/g AIN-93G diet) or 0.6% soy extract (containing genistein at 750 ㎍/g AIN-93G diet) until they were sacrificed. Tumor growth was significantly reduced in the groups treated with genistein and soy extract compared to the control group. The results of the proliferating cell nuclear antigen (PCNA) assay also revealed that genistein and soy extract treatment reduced the proliferation of MDA-MB-231 cells in vivo. In the present study, dietary isoflavone was provided just before solid tumor formation, and thus the timing of dietary isoflavone administration may be critical to the suppression of tumor growth.
목차
Abstract
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
ACKNOWLEDGEMENT
REFERENCES
참고문헌 (30)
참고문헌 신청
Ferlay J, Bray F, Pisani P, Parkin DM. 2001. GLOBOCAN 2000: Cancer Incidence, Mortality and Prevalence Worldwide, Version 1.0. IARC CancerBase No. 5. IARC Press, Lyon.
Lee HP, Gourley L, Duffy SW, Esteve J, Lee J, Day NE. 1991. Dietary effects on breast-cancer risk in Singapore. Lancet 337: 1197-1200.
National Research Council. 1994. Strategies for improving risk assessment. In Science and judgment in risk assessment. National Academy Press, Washington DC. p 79-84.
Barnes S. 1998. Phytoestrogens and breast cancer. Baillieres Clin Endocrinol Metab 12: 559-579.
Dixon RA, Ferreira D. 2002. Genistein. Phytochemistry 60: 205-211.
Lee HP, Gourley L, Duffy SW, Esteve J, Lee J, Day NE. 1991. Dietary effects on breast-cancer risk in Singapore. Lancet 337: 1197-1200.
National Research Council. 1994. Strategies for improving risk assessment. In Science and judgment in risk assessment. National Academy Press, Washington DC. p 79-84.
Barnes S. 1998. Phytoestrogens and breast cancer. Baillieres Clin Endocrinol Metab 12: 559-579.
Dixon RA, Ferreira D. 2002. Genistein. Phytochemistry 60: 205-211.
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Cell Survival, Apoptosis and AMPK-COX-2 Signaling Pathway of Mammary Tumor Cells after Genistein Treatment Combined with Estrogen
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Biotransformation of Free Isoflavones by Bacillus Species Isolated from Traditional Cheonggukjang
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Induction of Caspase-3 Dependent Apoptosis in Human Ovarian Cancer SK-OV-3 Cells by Genistein
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Isoflavone 강화 기능성 계란 생산 : 난황내 Genistein 전이 효율 개선
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[P8-318] Differential regulation of Grp78 in MCF-7 and MDA-MB-231 breast tumor cellsby genistein exposure and its implication in chemotheraphy
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Induction of Quinone Reductase Activity by Genistein, Soybean Isoflavone
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[P10-143] Protein Expression Profiling Analysis of Human Breast Cancer Cells Treated with Genistein
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[P8-77] Genistein의 지방축적 억제 효과
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Soy Isoflavones and Soyasaponins: Characteristics and Physiological Functions
Applied Biological Chemistry
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Isoflavone Contents in Some Varieties of Soybean
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[S12-2] Soy Isoflavones and Bone Health
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[P8-205] Effect of Genistein Supplementation on Stimulation of the Proliferation, Differentiation and Mineralization of Osteoblastic ROS 17/2.8 Cell
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Inhibitory Effects of Genistein and Water Extracts of Various Herbs on Histamine Release
Applied Biological Chemistry
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Pepper Seed Extract Inhibited Adhesion, Migration and Invasion in MDA-MB-231 and MCF-7 Breast Cancer Cell lines
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Genistein Combined with Exercise Improves Lipid Profiles and Leptin Levels in C57BL/6J Mice Fed a High Fat Diet
Food Science and Biotechnology
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Effect of Low Doses of Genistein and Equol on Protein Expression Profile in MCF-7 Cells
Food Science and Biotechnology
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이 논문의 저자 정보
이 논문과 함께 이용한 논문
LPS 주사한 BALB/c 마우스에서 Genistein의 산화적 스트레스 억제효과 및 항염증 효과
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UCI(KEPA) : I410-ECN-0101-2009-511-016553507