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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2007.10
- 수록면
- 710 - 718 (9page)
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초록· 키워드
오류제보하기
This study was designed to investigate the effects of plum(Prunus salicina Lindl. cultivars 'Oishiwase', 'Formosa', and 'Soldam') extracts on the proliferation as well as inhibition of human epithelial cells(HaCaT), human cervical carcinoma (HeLa, SiHa, and C33A) cells, and human stomach adenocarcinoma(SNU 638) cells. Dried plum was sequentially extracted and fractionated by hexane(KC-01), chloroform(KC-02), ethyl acetate(KC-03), n-butanol(KC-04), water(KC- 05), methanol(KC-6), and hot water extract(KC-07). The epithelial and cancer cells were exposed for 48 h to 50μg/mL of plum extract in vitro, and were then analysed by a sulforhodamin B(SRB) staining assay. The methanol extract (KCP- 6) of 'Formosa' proliferated not only the HaCaT cells(147.3%), but also the cervical carcinoma C33A cells(167.8%). The ethyl acetate extract of 'Soldam'(KCJ-3) significantly reduced the proliferation rate of the HPV positive cervical carcinoma cells, at 61.5% for the SiHa cells and 70.5% for the HeLa cells. In the C33A cells, which are HPV negative cervical carcinoma cells, the hexane fractions of 'Formosa'(KCP-1) and 'Oishiwase'(KCD-1) markedly suppressed proliferation activity at 20.4% and 61.7%, respectively. However, the proliferation rate of the normal epithelial cells(HaCaT cell) was not reduced the proliferation rate by KCJ-3, KCP-1, or KCD-1. There were no significant effects on proliferation of the stomach cancer cells(SNU 638) by any of the extracts or fractions of the plum cultivars. These results suggest that the anti-proliferative effects of the plum cultivars were selective to the cancer cell origin. In conclusion, we found that several plum cultivar extracts, especially, the ethyl acetate fraction of 'Soldam'' and the hexane fraction of ''Formosa', have anti-proliferative activity toward human cervical carcinoma cells. However, further investigation is needed to assess the molecular mechanisms that mediate the antiproliferation activities of the plum cultivars.
목차
Abstract
서론
재료 및 방법
결과 및 고찰
요약 및 결론
문헌
참고문헌 (18)
참고문헌 신청
1. [학술지(정기간행물)] - / 2007 / Protective effect of Sanguinarine on Ultravilolet B-mediated damgas in SKH-1 hairless mouse skin Implication for prevention of skin cancer 83 : 986 ~ 993
2. [학술지(정기간행물)] - / 1992 / A review of the epidemiological evidence : 1 ~ 29
3. [학술지(정기간행물)] - / 1999 / Morphological characteristics and principal component analysis of plums 17 (1) : 22 ~ 28
4. [학술지(정기간행물)] - / 1998 / Selection of suitable pollinizers for major Japanese plums 39 : 560 ~ 563
5. [학술지(정기간행물)] - / 1990 / An overview of the epidemiological evidence linking diet and cancer : 119 ~ 131
2. [학술지(정기간행물)] - / 1992 / A review of the epidemiological evidence : 1 ~ 29
3. [학술지(정기간행물)] - / 1999 / Morphological characteristics and principal component analysis of plums 17 (1) : 22 ~ 28
4. [학술지(정기간행물)] - / 1998 / Selection of suitable pollinizers for major Japanese plums 39 : 560 ~ 563
5. [학술지(정기간행물)] - / 1990 / An overview of the epidemiological evidence linking diet and cancer : 119 ~ 131
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UCI(KEPA) : I410-ECN-0101-2009-594-016038104