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The prickly pear (Opuntia spp.) is a member of the Cactaceae family and is widely distributed throughout the world. Most of Cactaceae family is known to be therapeutic and improvable properties for various body disturbances and Opuntia humifusa (OH) is a member of the Cactaceae family. This study was performed to evaluate the skin and eye irritation of OH extract in male New Zealand White rabbits. In skin irritation test, any clinical signs were not seen and there were no observed body weight changes and gross pathologic findings after OH treatment for 24 hours. Also, there were no observed erythema, eschar, and edema on intact and abraded skin and the Primary irritation index was 0. In eye irritation test, there were no chemosis in any eye of rabbits treated with OH extract 0.1 ㎖. The reactions were examined for 7 days after OH treatment. No eye irritation was observed in the eyes treated with the OH extract. Taken together, these results indicate that OH extract may be non-irritant materials on skin and eye.

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UCI(KEPA) : I410-ECN-0101-2009-510-016249892