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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2007.12
- 수록면
- 405 - 409 (5page)
이용수
초록· 키워드
오류제보하기
The present study was conducted to investigate the effects of coicis on vaginal opening day, estrous cycle and growth of rats. To examine the parameters mentioned above, we performed a pubertal onset assay using immature Sprague-Dawley female rats. Twenty one-day-old rats were orally administered coicis (125 or 625 ㎎/㎏) or tamoxifen (0.1 ㎎/㎏), an estrogen receptor antagonist, for 30 days. Vaginal opening was observed at 34.43 ㎎/㎏ 1.09 days of age in control rats. The mean vaginal opening day was delayed by about 1 day to 35.30 ± 0.35 days and 35.40 ± 1.13 days by the treatment with 125 ㎎/㎏ and 625 ㎎/㎏ of coicis, respectively. In contrast, tamoxifen significantly advanced the day of vaginal opening to 24 days, indicative of its estrogenic action. Coicis (125 ㎎/㎏) prolonged estrous cycle in 60% of rats, leading to 7.08 ± 3.38 days from 5.78 ± 2.13 days in control animals, although a high dose (625 ㎎/㎏) did not further prolonged it. In contrast, tamoxifen stopped the estrous cycle at diestrus stage. Coicis neither induced clinical signs nor enhanced body weight gain, whereas tamoxifen decreased body weight gain as well as feed and water consumptions. Based on the effects on vaginal opening time and estrous cycle, coicis was confirmed to possess an antiestrogenic activity without adverse effects. Therefore, it is suggested that coicis could be a candidate for the delay of initial menstruation, preventing early reduction in the growth of youngsters in gradually-growing animals or humans.
목차
재료 및 방법
결과
고찰
참고문헌
참고문헌 (21)
참고문헌 신청
1. [학술지(정기간행물)] - Allen / 1924 / The induction of sexually mature condition in immature females by injection of the ovarian follicular hormone : 577 ~ 588
2. [학술지(정기간행물)] - Ashby, J / 1997 / Activity of raloxifene in immature and ovariectomized rat uterotrophic assays 25 : 226 ~ 231
3. [학술지(정기간행물)] - Brown, J.J / 2006 / Growth in precocious puberty 73 : 81 ~ 88
4. [학술지(정기간행물)] - Chang, M.J / 2007 / uterotrophic response of soy isoflavone intake in rats 10 : 300 ~ 307
5. [학술지(정기간행물)] - Clark, R.L / 1999 / Endpoints of reproductive system development. In An Evaluation and Interpretation of Reproductive Endpoints for Human Health Risk Assessment : 10 ~ 27
2. [학술지(정기간행물)] - Ashby, J / 1997 / Activity of raloxifene in immature and ovariectomized rat uterotrophic assays 25 : 226 ~ 231
3. [학술지(정기간행물)] - Brown, J.J / 2006 / Growth in precocious puberty 73 : 81 ~ 88
4. [학술지(정기간행물)] - Chang, M.J / 2007 / uterotrophic response of soy isoflavone intake in rats 10 : 300 ~ 307
5. [학술지(정기간행물)] - Clark, R.L / 1999 / Endpoints of reproductive system development. In An Evaluation and Interpretation of Reproductive Endpoints for Human Health Risk Assessment : 10 ~ 27
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UCI(KEPA) : I410-ECN-0101-2009-510-016249978