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Medical benefits of the vegetables of genus Allium have been documented throughout the recorded history. Allium vegetables and/or their constituents have been shown to reduce the risk of cardiovascular diseases and cancer. Garlic has been used in various countries of Asia and Europe as food supplement and medicine from old times. Epidemiological studies made a suggestion that the intake of garlic is correlated with a reduced incidence of various digestive organ cancer. Although onion is vegetables widely consumed by human and epidemiological studies show an inverse association between vegetables consumption and cancer risk, effect of onion has not known clearly. In the present study, it was designed to investigate the effect of garlic and onion extracts (raw, heated to 110, 120, 130, 140 or 150℃) on the five kinds of human cancer cells (LOVO, NCI-H460, MCF-7, MKN-45 and PC-3). Cell viability was determined with a colormetric assay using water-soluble tetrazolium salt (WST-1). The growth of human cancer cells was inhibited by extracts of garlic heated at high degrees (130, 140 or 150℃). Also, the cancer cells-inhibitory effects of heated, especiaaly at 130 and 150℃, extracts of onion were superior to that of raw extract. These results suggest that Allium (garlic and onion) extracts might have a potential preventive effect on human cancer cells.

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UCI(KEPA) : I410-ECN-0101-2009-510-016362787