지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.9
- 수록면
- 195 - 199 (5page)
이용수
초록· 키워드
오류제보하기
It has been reported that hepatic microsomal cytochrome P450 (CYP) 2E1 is responsible for the metabolism of chlorzoxazone (CZX) to 6-hydroxychlorzoxazone. The present study was undertaken to assess the possible interaction of rutaecarpine, an alkaloid originally isolated from the unripe fruit of Evodia rutaecarpa, with CZX. Male Spraque-Dawley rats were administered with 80 mg/kg/day of oral rutaecarpine for three consecutive days. Twenty four hr after the pre-treatment with rutaecarpine, the rats were treated with 20 ㎎/㎏ of intravenous CZX. Rat hepatic microsomes isolated from rutaecarpine-treated rats showed greater (50% increase) activity of p-nitrophenol hydroxylase (a marker of CYP2E1) when compared with the control rats. Compared with control rats, the AUC of CZX was significantly smaller (84% decrease) possibly due to significantly faster CL (646% increase) in rats pretreated with rutaecarpine. This could be, at least partially, due to induction of CYP2E1 by rutaecarpine.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS AND DISCUSSION
ACKNOWLEDGEMENTS
REFERENCES
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Effects of Rutaecarpine on the Pharmacokinetics of Caffeine and Its Three Metabolites in Rats
Biomolecules & Therapeutics(구 응용약물학회지)
2011 .01
-
Metabolism of Rutaecarpine by Rat Liver Microsomes
대한약학회 학술대회
2003 .01
-
The Effects of Rutaecarpine on the Pharmacokinetics of Acetaminophen in Rats
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2007 .01
-
Effect of Phenobarbital on the Pharmacokinetics of Rutaecarpine and its Metabolite in Rats
Biomolecules & Therapeutics(구 응용약물학회지)
2008 .01
-
A Simple Synthesis of Rutaecarpine
대한약학회 학술대회
2001 .01
-
Effects of Glucose Supplementation on the Pharmacokinetics of Intravenous Chlorzoxazone in Rats with Water Deprivation for 72 Hours
대한약학회 학술대회
2003 .01
-
General Neuropharmacology of Rutaecarpine, a Quinazolinocarboline Alkaloid
The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmacology
2004 .01
-
Effects of Rutaecarpine on Hydrogen Peroxide-Induced Apoptosis in Murine Hepa-1c1c7 Cells
Biomolecules & Therapeutics(구 응용약물학회지)
2012 .01
-
Complete Nucleotide Sequence of Cytochrome P450 2E1 Expressed in the Rat Brain
대한의생명과학회지
2005 .06
-
Effects of Water Deprivation on Drug Pharmacokinetics: Correlation between Drug Metabolism and Hepatic CYP Isozymes
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2008 .01
-
Metabolism and Disposition of Chlorzoxazone in Rats : Effects of Ethanol and Disulfiram
한국독성학회지
1993 .06
-
Nonylphenol이 CYP17 및 CYP19발현에 미치는 영향
Environmental Analysis Health and Toxicology
2005 .09
-
Xylene에 의한 CYP2B1/2의 유도와 대사에 있어서 toluene의 영향
한국산업보건학회지
2009 .01
-
Purification and Characterization of the Rat Liver CYP2D1 and Utilization of Reconstituted CYP2D1 IN Caffeine Metabolism
한국독성학회지
1997 .03
-
Effects of a New Neuroprotective Agent KR-31378 on Liver Cytochrome P450s in Male Sprague Dawley Rats
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2003 .01
-
Effects of CYP1A2$^*$1C and CYP1A2$^*$1F Genotypes on the Activity and Inducibility of CYP1A2 Determined by Urinary Caffeine Metabolite Ratio in Koreans
Molecular & cellular toxicology
2007 .01
-
한약재의 Cytochrome P450 결합관련 안전성에 관한 연구
대한한방내과학회지
2013 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2009-513-015017277