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Decreased of Clusterin mRNA Expression of Epididymis Following Exposure to Bisphenol A Diglycidyl Ether during Gestation and Lactation in Sprague-Dawley Rats
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Type
Academic journal
Author
Journal
The Korean Society of Environmental Toxicology Environmental Analysis Health and Toxicology Vol.23 No4 KCI Accredited Journals SCOPUS
Published
2008.12
Pages
291 - 299 (9page)

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Background
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Decreased of Clusterin mRNA Expression of Epididymis Following Exposure to Bisphenol A Diglycidyl Ether during Gestation and Lactation in Sprague-Dawley Rats
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Abstract· Keywords

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Bisphenol A diglycidyl ether(BADGE)는 비스페놀 A와 에피클로로하이드린의 축합에 의해 만들어지는 물질로 상업용 액상 에폭시 수지의 주성분이다. 본 연구는 clusterin mRNA 발현이 BADGE의 노출된 생식기계 독성에 연관되어 있는지를 연구하기 위해 수행하였다. BADGE는 SPF Sprague-Dawley 임신 랏트에 임신 6일부터 수유기까지 하루에 한 번 0(대조군)과 375㎎/㎏/day를 경구 투여하였다. 수컷 새끼는 일반 사항과 몸무게, 일반 발달 지표(예, 항문과 생식기 사이의 거리, 이개개전, 절치붕출, 유두잔류, 안검개열, 고환하강, 포피박리 등) 등을 관찰하였다. 대조군과 투여군에서 다섯 마리의 수컷 새끼는 출생 후 3, 6와 9주에 부검하여 부고환의 조직학적 변화 등을 관찰하였다. BADGE 375㎎/㎏/day 투여군에서 항문과 생식기 사이의 거리는 대조군보다 길어지는 경향을 보였다. 출생 후 6주와 9주에서 부고환의 상대 무게는 대조군보다 약간 증가하였으나 조직학적인 변화는 관찰되지 않았다. BADGE 투여군에서 clusterin mRNA 발현량은 대조군에 비해 3주에 56%, 6주에 57% 그리고 9주에 86% 감소하였다. 이런 결과는 랏트의 부고환에서 clusterin은 BADGE에 반응하는 유전자 중 하나일 수 있다는 가능성을 나타낸다.
#bisphenol A diglycidyl ether #clusterin expression #development #rat epididymis #gestation and lactation period

Contents

요약
INTRODUCTION
METHODS
RESULTS
DISCUSSION
CONCLUSION
ACKNOWLEDGMENTS
REFERENCE

References (34)

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1. [학술지(정기간행물)] - Blaschuk O / 1983 / Purification and characterization of a cell-aggregating factor (clusterin), the major glycoprotein in ram rete testis fluid / J Biol Chem 258 : 7714 ~ 7720 google schola 2. [학술지(정기간행물)] - Graham S / 1986 / The expression of ano-genital distance data in the mouse / Physiol Behav 36 : 103 ~ 104 google schola 3. [단행본] - Hanley TR / 1996 / DGEBPA: Two Generation Oral Gavage Study in Sprague-Dawley Rats / Dow Chemical Co google schola 4. [학술지(정기간행물)] - Hinton BT / 1996 / The role of the epididymis in the protection of spermatozoa / Dev Biol 33 : 61 ~ 102 google schola 5. [학술지(정기간행물)] - Hinton BT / 1995 / Epididymal epithelium:its contribution to the formation of a luminal fluid microenvironment / Microsc Res Tech 30 : 67 ~ 81 google schola

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