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Formaldehyde (FA) is an important substance to induce sick house syndrome such as asthma and allergy in respiratory system. However, the mechanism of lung inflammation due to FA exposure has not been elucidated. Mitogen activated protein kinases (MAPKs) such as JNKs and p38 MAPK and nuclear factor kappa B (NF-κB) have been reported to be associated with the development of apoptosis in respiratory system. Thus, this study was conducted to investigate the effect of FA on apoptosis and its relationship between JNK, p38 MAPK, NF-κB in cultured HEL299 cells, embryonic lung cells. In this study, FA decreased cell viability of lung cells in a dose-dependent manner (＞100 μM). Indeed, FA decreased Bcl-2 expression but increased Bax expression in lung cells. In addition, FA also increased the cleaved form of caspase-3. FA-induced decrease of cell viability was blocked by the treatment of SP600125 (JNK inhibitor), SB203580 (p38 MAPK inhibitor), PDTC (NF-κB inhibitor), and SN-50 (NF-κB inhibitor). FA increased JNK and p38 MAPK and NF-κB activation using Western immunoblotting analysis. In conclusion, FA induced apoptosis via JNK, p38 MAPK, and NK-kB activation in cultured HEL299 cells.
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참고문헌 (36)
참고문헌 신청
1. [학술지(정기간행물)] - An, S. / 2007 / Lung injury after ischemia-reperfusion of small intestine in rats involves apoptosis of type II alveolar epithelial cells mediated by TNFalpha and activation of Bid pathway / Apoptosis 12 (11) : 1989 ~ 2001
2. [학술지(정기간행물)] - Baccioglu, A. / 2007 / An unusual form of formaldehyde-induced lung disease / Allergol. Immunopathol. (Madr) 35 (3) : 110 ~ 112
3. [학술지(정기간행물)] - Bradford, M.M. / 1976 / A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding / Anal. Biochem 72 : 248 ~ 254
4. [학술지(정기간행물)] - Buschmann, J. / 1996 / Embryotoxicity study of monomeric 4,4'-methylenediphenyl diisocyanate (MDI) aerosol after inhalation exposure in Wistar rats / Fundam. Appl. Toxicol 32 (1) : 96 ~ 101
5. [학술지(정기간행물)] - Callas, P. W. / 1996 / Lung cancer mortality among workers in formaldehyde industries / J. Occup. Environ. Med 38 (8) : 747 ~ 748
2. [학술지(정기간행물)] - Baccioglu, A. / 2007 / An unusual form of formaldehyde-induced lung disease / Allergol. Immunopathol. (Madr) 35 (3) : 110 ~ 112
3. [학술지(정기간행물)] - Bradford, M.M. / 1976 / A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding / Anal. Biochem 72 : 248 ~ 254
4. [학술지(정기간행물)] - Buschmann, J. / 1996 / Embryotoxicity study of monomeric 4,4'-methylenediphenyl diisocyanate (MDI) aerosol after inhalation exposure in Wistar rats / Fundam. Appl. Toxicol 32 (1) : 96 ~ 101
5. [학술지(정기간행물)] - Callas, P. W. / 1996 / Lung cancer mortality among workers in formaldehyde industries / J. Occup. Environ. Med 38 (8) : 747 ~ 748
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UCI(KEPA) : I410-ECN-0101-2009-510-019510689