지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.12
- 수록면
- 99 - 105 (7page)
이용수
초록· 키워드
오류제보하기
In this research, the genotoxic effects of Pinelliae Rhizoma (PR) extracts, one of famous herbal agents in Korean medicine were evaluated using the mouse micronucleus test. PR extracts was administered once a day for 2 continuous days by oral gavage to male ICR mice at doses of 2000, 1000, and 500 ㎎/㎏. Cyclophosphamide was used as a known genotoxic agent in a positive control. The appearance of a micronucleus is used as an index for genotoxic potential. No PR extracts treatment-related abnormal clinical signs, body weight changes and mortalities were detected. Significant (p<0.01) increases of the numbers of polychromatic erythrocytes contain micronucleus in prepared bone marrow cells were detected in CPA and PR extracts 2000 ㎎/㎏ treated groups as compared with intact control, respectively. The results of intraperitoneal dose mouse bone marrow cell micronucleus test of PR extracts were positive in the present study. It is considered that there were no problems from cytotoxicity of PR extracts tested in this study because the polychromatic erythrocyte ratio was detected as > 0.42 in all tested groups.
목차
Ⅰ. Introduction
Ⅱ. Materials and Methods
Ⅲ. Results
Ⅳ. Discussion
Ⅴ. Conclusion
Ⅵ. Acknowledgment
Ⅶ. References
참고문헌 (29)
참고문헌 신청
1. [학술지(정기간행물)] - Ho, S.T. / 1975 / Studies on Pinellia ternate Breitenbach. Report I. Antiemetic action of Pinellia ternata Breitenbach and its components / Taiwan Yao Hsueh Tsa Chih 27 : 41 ~ 46
2. [학술지(정기간행물)] - Maki, T. / 1987 / An antiemetic principle of Pinellia ternata Tuber / Plant Med. 53 : 410 ~ 414
3. [학술지(정기간행물)] - 이지은 / 2003 / 반하의 4주 반복투여독성 평가 / Laboratory Animal Research 19 (3) : 127 ~ 141
4. [학술지(정기간행물)] - Kurata, K. / 1998 / Quantitative analysis of anti-emetic principle in the tubers of Pinellia ternata by enzyme immunoassay / Plant Med. 64 : 645 ~ 648
5. [학술지(정기간행물)] - Li, Y.L. / 2007 / A flavonoid glycoside isolated from Smilax china L. rhizome in vitro anticancer effects on human cancer cell lines / J. Ethnopharmacol. 113 : 115 ~ 124
2. [학술지(정기간행물)] - Maki, T. / 1987 / An antiemetic principle of Pinellia ternata Tuber / Plant Med. 53 : 410 ~ 414
3. [학술지(정기간행물)] - 이지은 / 2003 / 반하의 4주 반복투여독성 평가 / Laboratory Animal Research 19 (3) : 127 ~ 141
4. [학술지(정기간행물)] - Kurata, K. / 1998 / Quantitative analysis of anti-emetic principle in the tubers of Pinellia ternata by enzyme immunoassay / Plant Med. 64 : 645 ~ 648
5. [학술지(정기간행물)] - Li, Y.L. / 2007 / A flavonoid glycoside isolated from Smilax china L. rhizome in vitro anticancer effects on human cancer cell lines / J. Ethnopharmacol. 113 : 115 ~ 124
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Micronucleus Test of Picrorrhiza Rhizoma Aqueous Extract in Bone Marrow Cells of Male ICR Mice
Toxicological Research
2011 .06
-
Micronucleus Test of Bupleuri Radix Aqueous Extract in Bone Marrow Cells of Male ICR Mice
한국한의학연구원 논문집
2012 .08
-
컴퓨터 이미지 분석법을 이용한 마우스 골수세포에서 소핵의 계수
Toxicological Research
2002 .12
-
Micronucleus Test of Kong-Jin-Dan, a Polyherbal Formula, in Bone Marrow Cells of Male ICR Mice
Toxicological Research
2008 .09
-
Toxicity Study on Chinese Herbal Drugs Using the Micronucleus Assay in Murine Bone Marrow Erythrocytes
한국독성학회지
1989 .12
-
Micronucleus Test of DHU001, a Polyherbal Formula, in Bone Marrow Cells of Male ICR Mice
Toxicological Research
2009 .12
-
Micronucleus Test of Polycan™, β-Glucan Originated from Aureobasidium, in Bone Marrow Cells of Male ICR Mice
Toxicological Research
2008 .03
-
생쥐 골수세포 미소핵 검사에 의한 $^{32}P-colloid$의 유전독성에 관한 연구
대한핵의학회지
1992 .01
-
Aluminum oxide, calcium oxide, sodium tetraborate 처리에 의한 설치류 골수세포의 소핵유발 연구
Environmental Analysis Health and Toxicology
2009 .06
-
생쥐골수세포 미소핵검사에 의한 치료용량 방사성옥소($^{131}I$)의 유전독성 평가
대한핵의학회지
1993 .01
-
Single Oral Dose Toxicity Study of Pinelliae Rhizoma Aqueous Extract in ICR Mice
Toxicological Research
2009 .09
-
Evaluation of the Genetic Toxicity of Synthetic Chemicals (X) - In vivo Bone Marrow Micronucleus Assay of 17 Synthetic Chemicals In Mice -
한국환경성돌연변이·발암원학회지
2004 .03
-
ICR 마우스 골수세포를 이용한 십전대보탕 소핵시험
대한한의학방제학회지
2008 .01
-
마우스를 이용한 Clean Natural에 대한 소핵시험
한국환경보건학회지
2005 .01
-
Genotoxicity Assessment of Erythritol by Using Short-term Assay
Toxicological Research
2013 .12
-
In vivo Micronucleus Assay - Historical Review and Current Improvement
한국환경성돌연변이·발암원학회지
2003 .09
-
Genotoxicity Test on 3,9-Diferuloyl-6-oxopterocarpen, a New Agent Candidate for Anti-aging Material
Laboratory Animal Research
2008 .03
-
The Micronucleus Test of CD-1 (ICR) Mice using Acridine Orange Staining
한국실험동물학회 학술발표대회 논문집
2010 .08
-
Chemoprotective Effects of Hesperidin Against Genotoxicity Induced by Cyclophosphamide in Mice Bone Marrow Cells
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2008 .01
-
HMC05의 경구투여 소핵시험 및 복귀돌연변이 시험
대한본초학회지(본초분과학회지)
2010 .01
이 논문의 저자 정보
이 논문과 함께 이용한 논문
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2010-519-002517423