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논문 기본 정보

자료유형
학술저널
저자정보
Hyun-A Lee (원광대학교) Sunhwa Hong (원광대학교) Hong-Geun Oh (Huvet) Sang-Ho Park (Korea DNA Valley) Youn-Chul Kim (원광대학교) Gil-Saeng Jeong (원광대학교) Okjin Kim (원광대학교)
저널정보
한국실험동물학회 Laboratory Animal Research Laboratory Animal Research Vol.26 No.1
발행연도
2010.3
수록면
21 - 29 (9page)

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Infection with Helicobacter pylori (H. pylori) is strongly associated with duodenal and gastric ulcers. Substantial epidemiological data has revealed that high rates of H. pylori infection might be related to high rates of gastric cancer and gastric adenocarcinoma. In this study, a medicinal herbal plant, Cinnamomum cassia, was examined and screened for anti-H. pylori activity. Seventy percent ethanol was used for herbal extraction. For anti-H. pylori activity screening, inhibitory zone tests as an in vitro assay and in vivo study using a Mongolian gerbil (Meriones unguiculatus) model were performed. Also, the safety of herbal compounds was evaluated by animal study. As a result of inhibitory zone test, Cinnamomum cassia extract demonstrated strong anti-H. pylori activities. Also, as results of in vivo animal studies, Cinnamomum cassia demonstrated strong therapeutic effects against H. pylori infection according to the criteria of histological examination and rapid urease test. As results of the safety study, after 28 days treatment of the Cinnamomum cassia extract, the animals were not detected any grossly and histological changes. These results demonstrate that it can be successfully cured against H. pylori infection and protected from H. pylori-induced pathology with Cinnamomum cassia. It could be a promising native herb treatment for patients with gastric complaints including gastric ulcer caused by H. pylori.

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