지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.3
- 수록면
- 8 - 16 (9page)
이용수
초록· 키워드
오류제보하기
Attention deficit hyperactivity disorder (ADHD) affects 4-12% of chool-age children worldwide and is characterized by three core symptoms: hyperactivity, inattention, and impulsivity. Although standard pharmacological treatments, such as methylphenidate and atomoxetine, are available, concerns about drug-induced psychological and cardiovascular problems, as well as growth retardation and sleep disturbances, highlight the continuing need for new therapeutic interventions. Using a neonatal hypoxia-induced hyperactivity model in rats, the potential positive role that oral administration of red ginseng extract may have in relation to the hyperactive phenotype was investigated. Hypoxia was induced in 2-day-old male Sprague-Dawley (SD) rat pups by placing them in a nitrogen chamber for 15 min. The neonatal hypoxia-induced rats showed a significant increase in hyperactivity phenotype, such as increased movement duration, movement distance, and rearing frequency, which was determined by monitoring their spontaneous locomotor activity using the Ethovision video tracking system. One week of oral treatment with red ginseng extract decreased the hyperactivity phenotype of the neonatal hypoxia-induced rats and increased the locomotor activity of the control rats. In the neonatal hypoxia-induced rats, expression of the norepinephrine transporter in the forebrain was increased, and red ginseng treatment partially prevented its up-regulation, while increasing its level in the control rats. Taken together, these results suggest that red ginseng extract decreased the neonatal hypoxia-induced hyperactivity phenotype, although it increased locomotor activity in normal animals.
목차
Abstract
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
ACKNOWLEDGEMENT
REFERENCES
참고문헌 (22)
참고문헌 신청
1. [단행본] - Arnsten AFT / 2001 / Stimulant Drugs and ADHD / Oxford University Press : 185 ~ 208
2. [학술지(정기간행물)] - Viggiano D / 2003 / Dopamine phenotype and behaviour in animal models: in relation to attention deficit hyperactivity disorder / Neurosci Biobehav Rev 27 (7) : 623 ~ 637
3. [단행본] - Sagvolden T / 2001 / Stimulant Drugs and ADHD / Oxford University Press : 221 ~ 238
4. [학술지(정기간행물)] - Adriani W / 2003 / The spontaneously hypertensive-rat as an animal model of ADHD: evidence for impulsive and non-impulsive subpopulations / Neurosci Biobehav Rev 27 (7) : 639 ~ 651
5. [학술지(정기간행물)] - Russell VA / 2002 / Hypodopaminergic and hypernoradrenergic activity in prefrontal cortex slices of an animal model for attentiondeficit hyperactivity disorder--the spontaneously hypertensive rat / Behav Brain Res 130 (1) : 191 ~ 196
2. [학술지(정기간행물)] - Viggiano D / 2003 / Dopamine phenotype and behaviour in animal models: in relation to attention deficit hyperactivity disorder / Neurosci Biobehav Rev 27 (7) : 623 ~ 637
3. [단행본] - Sagvolden T / 2001 / Stimulant Drugs and ADHD / Oxford University Press : 221 ~ 238
4. [학술지(정기간행물)] - Adriani W / 2003 / The spontaneously hypertensive-rat as an animal model of ADHD: evidence for impulsive and non-impulsive subpopulations / Neurosci Biobehav Rev 27 (7) : 639 ~ 651
5. [학술지(정기간행물)] - Russell VA / 2002 / Hypodopaminergic and hypernoradrenergic activity in prefrontal cortex slices of an animal model for attentiondeficit hyperactivity disorder--the spontaneously hypertensive rat / Behav Brain Res 130 (1) : 191 ~ 196
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
The effects of ren ginseng extracts on the hyperactivity behavior of animal models of attention deficit/hyperactivity disorder
고려인삼학회 학술대회
2008 .12
-
Controlled Gene Expression System under Hypoxia Conditions
항공우주의학 학술대회
2015 .05
-
저산소 모델에 따른 간장 기능 손상에 관한 연구
The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmacology
2000 .01
-
NF-κB Inhibitor Suppresses Hypoxia-induced Apoptosis of Mouse Pancreatic β-cell Line MIN6
대한의생명과학회지
2014 .03
-
저산소-허혈 손상이 신생 흰쥐의 뇌 선조체(Striatum) Monoamine 대사에 미치는 영향
Clinical and Experimental Pediatrics
2003 .01
-
Effect of Acute hypoxia on Plasma Endothelin in Rats
항공우주의학회지
1994 .04
-
저산소 환경에서의 유전자 발현 조절
항공우주의학회지
2015 .12
-
Vasorelaxing Effect of Hypoxia via Rho-kinase Inhibition on the Agonist-specific Vasoconstriction
Biomolecules & Therapeutics(구 응용약물학회지)
2008 .01
-
Gene therapy for neurologic disease using hypoxia-inducible neuron-specific VEGF expression system
항공우주의학 학술대회
2016 .05
-
Hypoxia Induced Multidrug Resistance of Laryngeal Cancer Cells via Hypoxia-inducible Factor-1α
Asian Pacific journal of cancer prevention : APJCP
2013 .01
-
Cytokine analysis in rat blood and liver exposed to intermittent hypoxia
항공우주의학 학술대회
2014 .11
-
Changes in drug metabolism during hypoxia/reoxygenation in isolated perfused rat
한국응용약물학회 춘계학술발표논문집
1997 .01
-
In vivo rat metabolism of red ginseng extract
고려인삼학회 학술대회
2011 .04
-
Attenuated effects of Neu2000 on hypoxia-induced synaptic activities in a rat hippocampus
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2014 .01
-
Robot Motion Tracking Analysis in Attention-Deficit/Hyperactivity Disorder
대한소아청소년정신의학회 학술대회논문집
2017 .05
-
Protective Effects of Red Ginseng Extract on Cadmium-induced Hepatic Toxicity in Rats
고려인삼학회 학술대회
2011 .04
-
Inhibitory Effects of Ginseng Total Saponins on Hypoxia-induced Dysfunction and Injuries of Cultured Astrocytes
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
1997 .01
-
Subacute Oral Toxicity Study of Korean Red Ginseng Extract in Sprague-Dawley Rats
Toxicological Research
2013 .12
-
허파혈관주위세포에서 저산소증에 의한 생존능의 억제와 유전자 발현의 변화
Tuberculosis and Respiratory Diseases
2004 .01
-
Ever Increasing Number of the Animal Model Systems for Attention Deficit/Hyperactivity Disorder: Attention, Please
Biomolecules & Therapeutics(구 응용약물학회지)
2008 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2010-524-003375739