지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.4
- 수록면
- 141 - 147 (7page)
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초록· 키워드
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Objectives : The aim of present study is to examine the effect of methanolic extract from the root of Bupleurum falcatum L. (BF) on acute cocaine-induced c-Fos expression in the rat caudate putamen (CPu), a major dopaminergic terminal.
Methods : Male Sprague-Dawley rats were subjected to an intraperitoneal injection with either cocaine hydrochloride (20 ㎎/㎏) or saline 30 min after an administration of either extract of BF (100 ㎎/㎏, i.p.) or vehicle. Animals were sacrificed 2 hr after treatment with cocaine or saline for immunohistochemistry. Quantification of brain slices was examined for c-Fos positive nuclei using light microscopy.
Results : Pretreatment with BF significantly attenuated cocaine-induced c-Fos expression in the rat CPu.
Conclusions : This finding suggests that BF has the inhibitory effect on cocaine-induced c-Fos expression in the rat CPu via possibly modulating the activities of central dopaminergic systems.
Methods : Male Sprague-Dawley rats were subjected to an intraperitoneal injection with either cocaine hydrochloride (20 ㎎/㎏) or saline 30 min after an administration of either extract of BF (100 ㎎/㎏, i.p.) or vehicle. Animals were sacrificed 2 hr after treatment with cocaine or saline for immunohistochemistry. Quantification of brain slices was examined for c-Fos positive nuclei using light microscopy.
Results : Pretreatment with BF significantly attenuated cocaine-induced c-Fos expression in the rat CPu.
Conclusions : This finding suggests that BF has the inhibitory effect on cocaine-induced c-Fos expression in the rat CPu via possibly modulating the activities of central dopaminergic systems.
목차
Ⅰ. Introduction
Ⅱ. Materials and Methods
Ⅲ. Results
Ⅳ. Discussion
Ⅴ. Acknowledgements
Ⅵ. References
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UCI(KEPA) : I410-ECN-0101-2010-519-003294558